Anal Melanoma With Neuroendocrine Differentiation: Report of a Case

Gennaro Ilardi, Danila Caroppo, Silvia Varricchio, Giulia Vita, Pierpaolo Di Lorenzo, Luigi Insabato, Gaetano De Rosa, Massimo Mascolo

Research output: Contribution to journalArticlepeer-review


Melanoma of the anal cavity is an uncommon malignant tumor with an aggressive clinical behavior. The presence of nonmelanocytic cell or tissue components, designated as divergent differentiation, is an unusual but well-documented phenomenon in melanoma. We experienced a rare case of amelanotic melanoma with neuroendocrine differentiation of the anal canal, occurring in a 68-year old woman. This tumor was characterized by a clear-cut radial growth phase and an invasive component composed of a diffuse small cells population positive for neuroendocrine markers with a focal but convincing co-expression of S100 protein. To the best of our knowledge, this represents the first case of neuroendocrine differentiation in a primary melanoma of the anal cavity. Although anal melanoma with neuroendocrine differentiation is exceptional, clinical practitioners should be aware of its possibility at this site.

Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalInternational Journal of Surgical Pathology
Issue number4
Publication statusPublished - Jun 3 2015


  • Amelanotic melanoma
  • Anal cavity
  • Immunohistochemistry
  • Neuroendocrine differentiation

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

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