Analgesic activity of carprofen on human experimental dental pain

G. Cruccu, G. Bini, N. Accornero, A. Berardelli, M. Manfredi

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of an orally administered single dose of placebo, acetylsalicylic acid (ASA) and (d,1)-6-chloro-α-methyl carbazole-2-acetic acid (carprofen) have been evaluted on an experimental pain model by electrical stimulation of dental pulp in man. ASA and carprofen showed a significant analgesic action, while placebo was ineffective. Analgesic activity of ASA and carprofen was similar. The two drugs were ineffective in modifying the pain threshold; on the contrary, the tolerance to the strongest painful sensation was significantly increased.

Original languageEnglish
Pages (from-to)1146-1149
Number of pages4
JournalArzneimittel-Forschung/Drug Research
Volume32
Issue number9
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

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