Abstract
The effects of an orally administered single dose of placebo, acetylsalicylic acid (ASA) and (d,1)-6-chloro-α-methyl carbazole-2-acetic acid (carprofen) have been evaluted on an experimental pain model by electrical stimulation of dental pulp in man. ASA and carprofen showed a significant analgesic action, while placebo was ineffective. Analgesic activity of ASA and carprofen was similar. The two drugs were ineffective in modifying the pain threshold; on the contrary, the tolerance to the strongest painful sensation was significantly increased.
| Original language | English |
|---|---|
| Pages (from-to) | 1146-1149 |
| Number of pages | 4 |
| Journal | Arzneimittel-Forschung/Drug Research |
| Volume | 32 |
| Issue number | 9 |
| Publication status | Published - 1982 |
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Chemistry(all)
- Pharmacology