The effects of an orally administered single dose of placebo, acetylsalicylic acid (ASA) and (d,1)-6-chloro-α-methyl carbazole-2-acetic acid (carprofen) have been evaluted on an experimental pain model by electrical stimulation of dental pulp in man. ASA and carprofen showed a significant analgesic action, while placebo was ineffective. Analgesic activity of ASA and carprofen was similar. The two drugs were ineffective in modifying the pain threshold; on the contrary, the tolerance to the strongest painful sensation was significantly increased.
|Number of pages||4|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry