Analgesic effect of morphine: A role for β-endorphin

Alberto E. Panerai, Paola Sacerdote, Anna Brini, Paolo Mantegazza

Research output: Contribution to journalArticlepeer-review

Abstract

Capsaicin, a neurotoxic agent that induces a decrease in hypothalamic β-endorphin, a specific antiserum and human β-endorphin fragment 6-31, a peptidergic β-endorphin antagonist have been used in the attempt of selectively affecting the function of β-endorphinergic system and of evaluating the possible role of this peptide in the analgesic effect of morphine. All 3 experimental approaches resulted in a decrease of the analgesia induced by morphine, thus suggesting that β-endorphin is involved in the effect of morphine.

Original languageEnglish
Pages (from-to)348-352
Number of pages5
JournalNeuroscience Letters
Volume74
Issue number3
DOIs
Publication statusPublished - Mar 9 1987

Keywords

  • Capsaicin
  • Morphine
  • Rat
  • β-endorphin

ASJC Scopus subject areas

  • Neuroscience(all)

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