Analgesic effect of topical diclofenac versus betamethasone after posterior segment surgery

G. Lesnoni, A. M. Coppe, G. Manni, B. Billi, M. Stirpe

Research output: Contribution to journalArticlepeer-review


Background: In clinical use, topical diclofenac, a nonsteroidal antiinflammatory, was found to be remarkably effective as an analgesic. A trial was therefore conducted to quantify and compare this effect with that of other drugs commonly used after posterior segment surgery. Methods: A single-blind, randomized study of 37 patients undergoing posterior segment surgery was conducted. On the day of surgery and for 30 days thereafter, one group received topical diclofenac 0.1% and one group received topical betamethasone 0.1%. Pain intensity was assessed by two standard psychologic tests, the McGill Pain Questionnaire (MPQ) and Scott’s Visual Analogic Scale (VAS). Results: The group receiving diclofenac had significantly lower pain scores on the MPQ at days 1 and 15 (P <0.05 and P <0.03, respectively). The VAS scores were also statistically lower for this group on day 15 (P <0.03). Conclusion: Topical diclofenac 0.1% has greater analgesic action than topical betamethasone 0.1% without the side effects of steroids, and may be useful after posterior segment surgery.

Original languageEnglish
Pages (from-to)34-36
Number of pages3
Issue number1
Publication statusPublished - 1995


  • Analgesic effect
  • Betamethasone
  • Diclofenac
  • McGill pain questionnaire
  • Posterior segment surgery
  • Visual analogic scale

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


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