Analgesic effects of topical ketamine

D. J. Kopsky, J. M Keppel Hesselink, A. Bhaskar, G. Hariton, V. Romanenko, R. Casale

Research output: Contribution to journalArticle

Abstract

Topical analgesics may play an important role in the management of chronic pain and have good tolerability. Systemic ketamine has limited usage as an anesthetic and along with its potential for addiction and dependence has not gained popularity as an analgesic compound. Topical ketamine however, is devoid of serious side effects, and thus can be used in the management of various pain states such as neuropathic pain and complex regional pain syndrome. Despite using high concentrations of topical ketamine, clinically significant side effects are rare. The measured plasma levels of ketamine and norketamine in various studies were mostly below the threshold of detection. Topical ketamine has been used as compounded formulations alone in concentrations from 0.5% to 20% or in combination with other (co-)analgesics. Its efficacy may depend on the choice of vehicle, the concentration and the pain state. Suboptimal concentration of ketamine and suboptimal pharmaceutical properties of the cream base might have contributed to the negative results of some studies. In this article we will review clinical studies involving the use of topical ketamine for pain.

Original languageEnglish
Pages (from-to)440-449
Number of pages10
JournalMinerva Anestesiologica
Volume81
Issue number4
Publication statusPublished - Apr 1 2015

Fingerprint

Ketamine
Analgesics
Complex Regional Pain Syndromes
Pain
Neuralgia
Pain Management
Chronic Pain
Anesthetics
Pharmaceutical Preparations

Keywords

  • Administration, topical
  • Analgesics - Neuralgia
  • Ketamine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Kopsky, D. J., Hesselink, J. M. K., Bhaskar, A., Hariton, G., Romanenko, V., & Casale, R. (2015). Analgesic effects of topical ketamine. Minerva Anestesiologica, 81(4), 440-449.

Analgesic effects of topical ketamine. / Kopsky, D. J.; Hesselink, J. M Keppel; Bhaskar, A.; Hariton, G.; Romanenko, V.; Casale, R.

In: Minerva Anestesiologica, Vol. 81, No. 4, 01.04.2015, p. 440-449.

Research output: Contribution to journalArticle

Kopsky, DJ, Hesselink, JMK, Bhaskar, A, Hariton, G, Romanenko, V & Casale, R 2015, 'Analgesic effects of topical ketamine', Minerva Anestesiologica, vol. 81, no. 4, pp. 440-449.
Kopsky DJ, Hesselink JMK, Bhaskar A, Hariton G, Romanenko V, Casale R. Analgesic effects of topical ketamine. Minerva Anestesiologica. 2015 Apr 1;81(4):440-449.
Kopsky, D. J. ; Hesselink, J. M Keppel ; Bhaskar, A. ; Hariton, G. ; Romanenko, V. ; Casale, R. / Analgesic effects of topical ketamine. In: Minerva Anestesiologica. 2015 ; Vol. 81, No. 4. pp. 440-449.
@article{f78f1a885ada44f3885d553a81916ce0,
title = "Analgesic effects of topical ketamine",
abstract = "Topical analgesics may play an important role in the management of chronic pain and have good tolerability. Systemic ketamine has limited usage as an anesthetic and along with its potential for addiction and dependence has not gained popularity as an analgesic compound. Topical ketamine however, is devoid of serious side effects, and thus can be used in the management of various pain states such as neuropathic pain and complex regional pain syndrome. Despite using high concentrations of topical ketamine, clinically significant side effects are rare. The measured plasma levels of ketamine and norketamine in various studies were mostly below the threshold of detection. Topical ketamine has been used as compounded formulations alone in concentrations from 0.5{\%} to 20{\%} or in combination with other (co-)analgesics. Its efficacy may depend on the choice of vehicle, the concentration and the pain state. Suboptimal concentration of ketamine and suboptimal pharmaceutical properties of the cream base might have contributed to the negative results of some studies. In this article we will review clinical studies involving the use of topical ketamine for pain.",
keywords = "Administration, topical, Analgesics - Neuralgia, Ketamine",
author = "Kopsky, {D. J.} and Hesselink, {J. M Keppel} and A. Bhaskar and G. Hariton and V. Romanenko and R. Casale",
year = "2015",
month = "4",
day = "1",
language = "English",
volume = "81",
pages = "440--449",
journal = "Minerva Anestesiologica",
issn = "0375-9393",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "4",

}

TY - JOUR

T1 - Analgesic effects of topical ketamine

AU - Kopsky, D. J.

AU - Hesselink, J. M Keppel

AU - Bhaskar, A.

AU - Hariton, G.

AU - Romanenko, V.

AU - Casale, R.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Topical analgesics may play an important role in the management of chronic pain and have good tolerability. Systemic ketamine has limited usage as an anesthetic and along with its potential for addiction and dependence has not gained popularity as an analgesic compound. Topical ketamine however, is devoid of serious side effects, and thus can be used in the management of various pain states such as neuropathic pain and complex regional pain syndrome. Despite using high concentrations of topical ketamine, clinically significant side effects are rare. The measured plasma levels of ketamine and norketamine in various studies were mostly below the threshold of detection. Topical ketamine has been used as compounded formulations alone in concentrations from 0.5% to 20% or in combination with other (co-)analgesics. Its efficacy may depend on the choice of vehicle, the concentration and the pain state. Suboptimal concentration of ketamine and suboptimal pharmaceutical properties of the cream base might have contributed to the negative results of some studies. In this article we will review clinical studies involving the use of topical ketamine for pain.

AB - Topical analgesics may play an important role in the management of chronic pain and have good tolerability. Systemic ketamine has limited usage as an anesthetic and along with its potential for addiction and dependence has not gained popularity as an analgesic compound. Topical ketamine however, is devoid of serious side effects, and thus can be used in the management of various pain states such as neuropathic pain and complex regional pain syndrome. Despite using high concentrations of topical ketamine, clinically significant side effects are rare. The measured plasma levels of ketamine and norketamine in various studies were mostly below the threshold of detection. Topical ketamine has been used as compounded formulations alone in concentrations from 0.5% to 20% or in combination with other (co-)analgesics. Its efficacy may depend on the choice of vehicle, the concentration and the pain state. Suboptimal concentration of ketamine and suboptimal pharmaceutical properties of the cream base might have contributed to the negative results of some studies. In this article we will review clinical studies involving the use of topical ketamine for pain.

KW - Administration, topical

KW - Analgesics - Neuralgia

KW - Ketamine

UR - http://www.scopus.com/inward/record.url?scp=84929997926&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929997926&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84929997926

VL - 81

SP - 440

EP - 449

JO - Minerva Anestesiologica

JF - Minerva Anestesiologica

SN - 0375-9393

IS - 4

ER -