TY - JOUR
T1 - Analgesic treatment in acute myocardial infarction
T2 - A comparison between indoprofen and morphine by a double-blind randomized pilot study
AU - Bressan, M. A.
AU - Costantini, M.
AU - Klersy, C.
AU - Marangoni, E.
AU - Meardi, G.
AU - Panciroli, C.
AU - Battaglia, A.
AU - Bruni, G.
AU - Sacchetti, G.
PY - 1985
Y1 - 1985
N2 - On the basis of the results of an earlier study, showing that i.v. indoprofen induced no clinically significant changes in hemodynamic parameters of patients with acute myocardial infarction (AMI), a double-blind randomized trial was carried out in 40 AMI patients to evaluate the analgesic activity of 400 mg i.v. indoprofen in comparison with 10 mg i.m. morphine hydrochloride. Pain severity was recorded before and at several intervals within 24 h after drug administration. The average analgesic response was prompt and progressive up to the 6th hour in both treatment groups, with no significant difference between drugs in various pain descriptors. However, the proportion of responding patients in the indoprofen group was greater than in the morphine group at all observation times, indicating a significant difference (p <0.05) in favor of indoprofen. In view of its good tolerability, i.v. indoprofen is worth considering in early AMI as an alternative to morphine in those patients in whom non-opiate analgesia might be preferable.
AB - On the basis of the results of an earlier study, showing that i.v. indoprofen induced no clinically significant changes in hemodynamic parameters of patients with acute myocardial infarction (AMI), a double-blind randomized trial was carried out in 40 AMI patients to evaluate the analgesic activity of 400 mg i.v. indoprofen in comparison with 10 mg i.m. morphine hydrochloride. Pain severity was recorded before and at several intervals within 24 h after drug administration. The average analgesic response was prompt and progressive up to the 6th hour in both treatment groups, with no significant difference between drugs in various pain descriptors. However, the proportion of responding patients in the indoprofen group was greater than in the morphine group at all observation times, indicating a significant difference (p <0.05) in favor of indoprofen. In view of its good tolerability, i.v. indoprofen is worth considering in early AMI as an alternative to morphine in those patients in whom non-opiate analgesia might be preferable.
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M3 - Article
C2 - 3912334
AN - SCOPUS:0022345248
VL - 23
SP - 668
EP - 672
JO - International Journal of Clinical Pharmacology and Therapeutics
JF - International Journal of Clinical Pharmacology and Therapeutics
SN - 0174-4879
IS - 12
ER -