Analysis and characterization of the X-ray beam produced by a PF device for radiotherapy applications

M. Sumini; A. Previti; D. Galassi; E. Ceccolini; F. Rocchi; D. Mostacci; A. Tartari; F. Pasi; A. Facoetti; G. Mazzini; R. Nano; A. Virelli; I. Zironi; G. Castellani; G. Cucchi; R. Orecchia

doi:10.1002/xrs.2621

Analysis and characterization of the X-ray beam produced by a PF device for radiotherapy applications

M. Sumini, A. Previti, D. Galassi, E. Ceccolini, F. Rocchi, D. Mostacci, A. Tartari, F. Pasi, A. Facoetti, G. Mazzini, R. Nano, A. Virelli, I. Zironi, G. Castellani, G. Cucchi, R. Orecchia

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

A plasma focus device, devoted to the study of a possible application to the radiotherapy treatment of malignant cells, has been recently put into operation. The low-energy (up to 200keV) X-rays are produced by conversion of the electron beam generated by the device during the pinch phase. The X-ray spectrum has already been fully characterized, and an initial campaign of irradiation of specific cell cultures has been completed. At present, the links between the operational parameters of the actual device, the beam intensity, and the cell irradiation effects are being analyzed, trying to evaluate the advantage of the very high dose rate that can be delivered, of the order of several Gy in a few tens of nanoseconds. Preliminary results on radiobiological effectiveness are presented and discussed.

Original language	English
Pages (from-to)	289-295
Number of pages	7
Journal	X-Ray Spectrometry
Volume	44
Issue number	4
DOIs	https://doi.org/10.1002/xrs.2621
Publication status	Published - Jul 1 2015

Keywords

Dose rate
Electron beam
Plasma Focus
Radiotherapy
X-ray

ASJC Scopus subject areas

Spectroscopy

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10.1002/xrs.2621

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Sumini, M., Previti, A., Galassi, D., Ceccolini, E., Rocchi, F., Mostacci, D., Tartari, A., Pasi, F., Facoetti, A., Mazzini, G., Nano, R., Virelli, A., Zironi, I., Castellani, G., Cucchi, G., & Orecchia, R. (2015). Analysis and characterization of the X-ray beam produced by a PF device for radiotherapy applications. X-Ray Spectrometry, 44(4), 289-295. https://doi.org/10.1002/xrs.2621

Sumini, M, Previti, A, Galassi, D, Ceccolini, E, Rocchi, F, Mostacci, D, Tartari, A, Pasi, F, Facoetti, A, Mazzini, G, Nano, R, Virelli, A, Zironi, I, Castellani, G, Cucchi, G & Orecchia, R 2015, 'Analysis and characterization of the X-ray beam produced by a PF device for radiotherapy applications', X-Ray Spectrometry, vol. 44, no. 4, pp. 289-295. https://doi.org/10.1002/xrs.2621

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abstract = "A plasma focus device, devoted to the study of a possible application to the radiotherapy treatment of malignant cells, has been recently put into operation. The low-energy (up to 200keV) X-rays are produced by conversion of the electron beam generated by the device during the pinch phase. The X-ray spectrum has already been fully characterized, and an initial campaign of irradiation of specific cell cultures has been completed. At present, the links between the operational parameters of the actual device, the beam intensity, and the cell irradiation effects are being analyzed, trying to evaluate the advantage of the very high dose rate that can be delivered, of the order of several Gy in a few tens of nanoseconds. Preliminary results on radiobiological effectiveness are presented and discussed.",

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AU - Galassi, D.

AU - Ceccolini, E.

AU - Rocchi, F.

AU - Mostacci, D.

AU - Tartari, A.

AU - Pasi, F.

AU - Facoetti, A.

AU - Mazzini, G.

AU - Nano, R.

AU - Virelli, A.

AU - Zironi, I.

AU - Castellani, G.

AU - Cucchi, G.

AU - Orecchia, R.

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KW - Dose rate

KW - Electron beam

KW - Plasma Focus

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KW - X-ray

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Analysis and characterization of the X-ray beam produced by a PF device for radiotherapy applications

Abstract

Keywords

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