Analysis of 138 consecutive ovarian cancer patients: Incidence and characteristics of familial cases

Stefano Greggi, Maurizio Genuardi, Pierluigi Benedetti-Panici, Rosa Cento, Giovanni Scambia, Giovanni Neri, Salvatore Mancuso

Research output: Contribution to journalArticle

Abstract

Eight families with two or more first-degree relatives affected with ovarian carcinoma were identified among a series of 138 consecutive ovarian cancer patients. History of breast cancer was reported in six of the eight families. Five of 19 patients with familial cancer developed ovarian cancer as a second primary tumor following breast carcinoma, whereas only 6 130 sporadic cases had a previous history of breast cancer. No significant difference was detected in clinical and pathological features between sporadic and familial cases. However, in three high-risk families ovarian cancer tended to develop at a younger age compared with other familial cases and with sporadic occurrences, and nulliparity was less frequent in the familial group. These observations emphasize the need to take into account multiple factors-in addition to positive family history-for the evaluation of genetic predisposition to ovarian carcinoma.

Original languageEnglish
Pages (from-to)300-304
Number of pages5
JournalGynecologic Oncology
Volume39
Issue number3
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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