TY - JOUR
T1 - Analysis of 138 consecutive ovarian cancer patients
T2 - Incidence and characteristics of familial cases
AU - Greggi, Stefano
AU - Genuardi, Maurizio
AU - Benedetti-Panici, Pierluigi
AU - Cento, Rosa
AU - Scambia, Giovanni
AU - Neri, Giovanni
AU - Mancuso, Salvatore
PY - 1990
Y1 - 1990
N2 - Eight families with two or more first-degree relatives affected with ovarian carcinoma were identified among a series of 138 consecutive ovarian cancer patients. History of breast cancer was reported in six of the eight families. Five of 19 patients with familial cancer developed ovarian cancer as a second primary tumor following breast carcinoma, whereas only 6 130 sporadic cases had a previous history of breast cancer. No significant difference was detected in clinical and pathological features between sporadic and familial cases. However, in three high-risk families ovarian cancer tended to develop at a younger age compared with other familial cases and with sporadic occurrences, and nulliparity was less frequent in the familial group. These observations emphasize the need to take into account multiple factors-in addition to positive family history-for the evaluation of genetic predisposition to ovarian carcinoma.
AB - Eight families with two or more first-degree relatives affected with ovarian carcinoma were identified among a series of 138 consecutive ovarian cancer patients. History of breast cancer was reported in six of the eight families. Five of 19 patients with familial cancer developed ovarian cancer as a second primary tumor following breast carcinoma, whereas only 6 130 sporadic cases had a previous history of breast cancer. No significant difference was detected in clinical and pathological features between sporadic and familial cases. However, in three high-risk families ovarian cancer tended to develop at a younger age compared with other familial cases and with sporadic occurrences, and nulliparity was less frequent in the familial group. These observations emphasize the need to take into account multiple factors-in addition to positive family history-for the evaluation of genetic predisposition to ovarian carcinoma.
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U2 - 10.1016/0090-8258(90)90256-K
DO - 10.1016/0090-8258(90)90256-K
M3 - Article
C2 - 2258075
AN - SCOPUS:0025641069
VL - 39
SP - 300
EP - 304
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 3
ER -