Analysis of 21 X-chromosomal STRs in an Algerian population sample

Asmahan Bekada, Soraya Benhamamouch, Abdallah Boudjema, Mustapha Fodil, Silvia Menegon, Carlo Torre, Carlo Robino

Research output: Contribution to journalArticle

Abstract

Twenty-one X-chromosomal short tandem repeat loci, including the six clusters of linked markers DXS10148-DXS10135-DXS8378 (Xp22), DXS7132-DXS10074-DXS10079 (Xq12), DXS6801-DXS6809-DXS6789 (Xq21), DXS7424-DXS101 (Xq22), DXS10103-HPRTB-DXS10101 (Xq26), DXS8377-DXS10146-DXS10134-DXS7423- DXS10011 (Xq28), and the loci DXS6800 and GATA172D05 were typed in a northwestern Algerian population sample (n∈=∈210; 104 men and 106 women). Allele and haplotype frequencies were calculated. No evidence of linkage disequilibrium was observed between pairs of loci within clusters of linked markers. At locus DXS10148, sequence analysis of a subset of alleles displaying unusual amplicon length (≥ 36 repeat units) and anomalous electrophoretic mobility showed that this marker has a complex molecular structure with different repeat variants within alleles of identical amplicon size.

Original languageEnglish
Pages (from-to)287-294
Number of pages8
JournalInternational Journal of Legal Medicine
Volume124
Issue number4
DOIs
Publication statusPublished - Jul 2010

Keywords

  • Algeria
  • DXS10148
  • Haplotype
  • Linkage disequilibrium
  • Short tandem repeat
  • X chromosome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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  • Cite this

    Bekada, A., Benhamamouch, S., Boudjema, A., Fodil, M., Menegon, S., Torre, C., & Robino, C. (2010). Analysis of 21 X-chromosomal STRs in an Algerian population sample. International Journal of Legal Medicine, 124(4), 287-294. https://doi.org/10.1007/s00414-009-0397-9