Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease

Francesca Nicosia; Antonella Alberici; Luisa Benussi; Laura Gasparini; Roberta Ghidoni; Federica Mazzoli; Orazio Zanetti; Giovanni Battista Frisoni; Cristina Geroldi; Giuliano Binetti

doi:10.1159/000051274

Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease

Francesca Nicosia, Antonella Alberici, Luisa Benussi, Laura Gasparini, Roberta Ghidoni, Federica Mazzoli, Orazio Zanetti, Giovanni Battista Frisoni, Cristina Geroldi, Giuliano Binetti

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article › peer-review

Abstract

A correlation between a 5-nucleotide deletion polymorphism in the A2M gene and an enhanced risk of developing Alzheimer's disease (AD) was reported. We studied this polymorphism in sporadic AD patients and patients with frontotemporal dementia (FTD) by using an electrophoretical separation of PCR products on a Metaphor gel. Our results did not show any significant difference between A2M-2 allelic frequency (p = 0.89) or genotype frequency (p = 0.97) in the two different clinical series and in control subjects. The frequencies were not significantly different after stratification by APOE ε4 status.

Original language	English
Pages (from-to)	305-308
Number of pages	4
Journal	Dementia and Geriatric Cognitive Disorders
Volume	12
Issue number	5
DOIs	https://doi.org/10.1159/000051274
Publication status	Published - 2001

Keywords

Alpha-2-macroglobulin
Alzheimer's disease
Apolipoprotein E

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Geriatrics and Gerontology

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10.1159/000051274

Cite this

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title = "Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease",

abstract = "A correlation between a 5-nucleotide deletion polymorphism in the A2M gene and an enhanced risk of developing Alzheimer's disease (AD) was reported. We studied this polymorphism in sporadic AD patients and patients with frontotemporal dementia (FTD) by using an electrophoretical separation of PCR products on a Metaphor gel. Our results did not show any significant difference between A2M-2 allelic frequency (p = 0.89) or genotype frequency (p = 0.97) in the two different clinical series and in control subjects. The frequencies were not significantly different after stratification by APOE ε4 status.",

keywords = "Alpha-2-macroglobulin, Alzheimer's disease, Apolipoprotein E",

author = "Francesca Nicosia and Antonella Alberici and Luisa Benussi and Laura Gasparini and Roberta Ghidoni and Federica Mazzoli and Orazio Zanetti and Frisoni, {Giovanni Battista} and Cristina Geroldi and Giuliano Binetti",

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T1 - Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease

AU - Nicosia, Francesca

AU - Alberici, Antonella

AU - Benussi, Luisa

AU - Gasparini, Laura

AU - Ghidoni, Roberta

AU - Mazzoli, Federica

AU - Zanetti, Orazio

AU - Frisoni, Giovanni Battista

AU - Geroldi, Cristina

AU - Binetti, Giuliano

PY - 2001

Y1 - 2001

N2 - A correlation between a 5-nucleotide deletion polymorphism in the A2M gene and an enhanced risk of developing Alzheimer's disease (AD) was reported. We studied this polymorphism in sporadic AD patients and patients with frontotemporal dementia (FTD) by using an electrophoretical separation of PCR products on a Metaphor gel. Our results did not show any significant difference between A2M-2 allelic frequency (p = 0.89) or genotype frequency (p = 0.97) in the two different clinical series and in control subjects. The frequencies were not significantly different after stratification by APOE ε4 status.

AB - A correlation between a 5-nucleotide deletion polymorphism in the A2M gene and an enhanced risk of developing Alzheimer's disease (AD) was reported. We studied this polymorphism in sporadic AD patients and patients with frontotemporal dementia (FTD) by using an electrophoretical separation of PCR products on a Metaphor gel. Our results did not show any significant difference between A2M-2 allelic frequency (p = 0.89) or genotype frequency (p = 0.97) in the two different clinical series and in control subjects. The frequencies were not significantly different after stratification by APOE ε4 status.

KW - Alpha-2-macroglobulin

KW - Alzheimer's disease

KW - Apolipoprotein E

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Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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