Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease

Francesca Nicosia, Antonella Alberici, Luisa Benussi, Laura Gasparini, Roberta Ghidoni, Federica Mazzoli, Orazio Zanetti, Giovanni Battista Frisoni, Cristina Geroldi, Giuliano Binetti

Research output: Contribution to journalArticle

Abstract

A correlation between a 5-nucleotide deletion polymorphism in the A2M gene and an enhanced risk of developing Alzheimer's disease (AD) was reported. We studied this polymorphism in sporadic AD patients and patients with frontotemporal dementia (FTD) by using an electrophoretical separation of PCR products on a Metaphor gel. Our results did not show any significant difference between A2M-2 allelic frequency (p = 0.89) or genotype frequency (p = 0.97) in the two different clinical series and in control subjects. The frequencies were not significantly different after stratification by APOE ε4 status.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalDementia and Geriatric Cognitive Disorders
Volume12
Issue number5
DOIs
Publication statusPublished - 2001

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Keywords

  • Alpha-2-macroglobulin
  • Alzheimer's disease
  • Apolipoprotein E

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

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