Analysis of Chlamydia pneumoniae-specific oligoclonal bands in multiple sclerosis and other neurologic diseases

Diego Franciotta, E. Zardini, R. Bergamaschi, L. M. Grimaldi, L. Andreoni, V. Cosi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective - Paired serum and cerebrospinal fluid (CSF) specimens were investigated for Chlamydia pneumoniae-specific oligoclonal bands (OCBs) to determine band specificity in multiple sclerosis (MS). Material and methods - Serum and CSF samples were collected from patients with relapsing-remitting MS (n = 56), other inflammatory (n = 18) or non-inflammatory (n = 15) neurologic diseases, and from 10 healthy controls. OCBs were determined with affinity immunoblotting of C. pneumoniae-specific IgG onto antigen-coated nitrocellulose paper after protein separation with agarose isoelectric focusing. Results - Chlamydia pneumoniae-specific OCBs were present in 5 of 56 patients with MS, and in 3 of 18 patients with other inflammatory neurologic diseases. Conclusions - The intrathecal production of C. pneumoniae-specific oligoclonal IgG occurs in a minority of patients with MS. This intrathecal anti-C. pneumoniae reactivity is likely part of a polyspecific humoral immune response in MS.

Original languageEnglish
Pages (from-to)238-241
Number of pages4
JournalActa Neurologica Scandinavica
Volume112
Issue number4
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Cerebrospinal fluid
  • Chlamydia pneumoniae
  • Multiple sclerosis
  • Oligoclonal bands

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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