Abstract
The aim of this study was to investigate the possible role of genetic alterations in the genesis and progression of cervical carcinomas. We analysed the 3, 7, X aneusomy of chromosomes and the status of the epidermal growth factor receptor (EGFR) gene by fluorescence in situ hybridisation (FISH) analysis. Polysomy of chromosomes 3 and X defined the transition from high-grade squamous intraepithelium lesions (HSIL) to cervical carcinoma. Chromosome 7 monosomy and polysomy did not show any statistical significant differences between the groups examined. When we compared the chromosomal aneusomies in all of the specimens using the Kruskal-Wallis test, significant differences (P=0.0001, P=0.0001 for chromosomes 3 and X, respectively) were observed. Using a ratio of the EGFR gene signals and chromosome 7 centromeric signals, no samples showed gene amplification. Our results demonstrate the importance of chromosomal 3 and X aneusomies in the development and progression from HSIL to cervical carcinoma, highlighting their usefulness as genetic markers for identifying SILs at high-risk of progression.
Original language | English |
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Pages (from-to) | 1624-1629 |
Number of pages | 6 |
Journal | European Journal of Cancer |
Volume | 40 |
Issue number | 10 |
DOIs | |
Publication status | Published - Jul 2004 |
Keywords
- Cervical carcinoma
- Genetic markers
- Progression
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology