Analysis of Circulating Mediators of Bone Remodeling in Prader-Willi Syndrome

G Brunetti, G Grugni, L Piacente, M Delvecchio, A Ventura, P Giordano, M Grano, G D'Amato, D Laforgia, A Crinò, M F Faienza

Research output: Contribution to journalArticle

Abstract

We tested the hypothesis that the levels of bone remodeling mediators may be altered in Prader-Willi syndrome (PWS). We assessed RANKL, OPG, sclerostin, DKK-1 serum levels, and bone metabolism markers in 12 PWS children (7.8 ± 4.3 years), 14 PWS adults (29.5 ± 7.2 years), and 31 healthy controls matched for sex and age. Instrumental parameters of bone mineral density (BMD) were also evaluated. Lumbar spine BMD Z-scores were reduced in PWS children (P 
Original languageItalian
Pages (from-to)635-643
Number of pages9
JournalCalcified Tissue International
Volume102
Issue number6
DOIs
Publication statusPublished - Jun 2018

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