TY - JOUR
T1 - Analysis of differential miRNA expression in primary tumor and stroma of colorectal cancer patients
AU - Della Vittoria Scarpati, Giuseppina
AU - Calura, Enrica
AU - Di Marino, Mariacristina
AU - Romualdi, Chiara
AU - Beltrame, Luca
AU - Malapelle, Umberto
AU - Troncone, Giancarlo
AU - De Stefano, Alfonso
AU - Pepe, Stefano
AU - De Placido, Sabino
AU - D'Incalci, Maurizio
AU - Marchini, Sergio
AU - Carlomagno, Chiara
PY - 2014
Y1 - 2014
N2 - Microarray technology was used to profile miRNA expression in primary tumor and stromal tissue from paraffin embedded material of 51 patients with colorectal cancer. 26 miRNAs resulted differentially expressed with at least 2-fold change in tumor tissue with respect to stroma (16 more expressed in the tumor and 10 more expressed in the stroma). 10/26 were confirmed as differentially expressed at qRTPCR: miR-200c-3p, miR-141-3p, miR-200b-3p, miR-200a-3p, miR-1246, miR-92a-3p, miR-194-5p, miR-192-5p, miR-3651-5p, and miR-574-3p. No significant association was found between miRNA expressions and stage at diagnosis, site of primary tumor, first site of metastasis, progression-free, or overall survival.
AB - Microarray technology was used to profile miRNA expression in primary tumor and stromal tissue from paraffin embedded material of 51 patients with colorectal cancer. 26 miRNAs resulted differentially expressed with at least 2-fold change in tumor tissue with respect to stroma (16 more expressed in the tumor and 10 more expressed in the stroma). 10/26 were confirmed as differentially expressed at qRTPCR: miR-200c-3p, miR-141-3p, miR-200b-3p, miR-200a-3p, miR-1246, miR-92a-3p, miR-194-5p, miR-192-5p, miR-3651-5p, and miR-574-3p. No significant association was found between miRNA expressions and stage at diagnosis, site of primary tumor, first site of metastasis, progression-free, or overall survival.
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U2 - 10.1155/2014/840921
DO - 10.1155/2014/840921
M3 - Article
C2 - 25143946
AN - SCOPUS:84904913539
VL - 2014
JO - BioMed Research International
JF - BioMed Research International
SN - 2314-6133
M1 - 840921
ER -