Analysis of factors affecting recurrence of hepatocellular carcinoma after liver transplantation with a special focus on inflammation markers

Valentina Rosa Bertuzzo, Matteo Cescon, Matteo Ravaioli, Gian Luca Grazi, Giorgio Ercolani, Massimo Del Gaudio, Alessandro Cucchetti, Antonietta D'Errico-Grigioni, Rita Golfieri, Antonio Daniele Pinna

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Systemic inflammation markers, such as neutrophil-to-lymphocyte ratio (NLR), have recently emerged as the prognostic factors for recurrence of liver tumors. Methods: We assessed the ability of NLR and of other variables to predict the outcomes of orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC). A retrospective analysis was performed in 219 patients with HCC who underwent OLT between 1997 and 2009, with a median follow-up of 40 months. Results: Overall 3- and 5-year patient survival rates were 76.6% and 70.7%, respectively. Overall 3- and 5-year recurrence-free survival (RFS) rates were 83.8% and 82.1%, respectively. On univariate analysis, the factors affecting overall survival were α-fetoprotein more than 30 ng/mL (P=0.006), NLR more than or equal to 5 (P

Original languageEnglish
Pages (from-to)1279-1285
Number of pages7
JournalTransplantation
Volume91
Issue number11
DOIs
Publication statusPublished - Jun 15 2011

Keywords

  • Inflammation markers
  • Liver transplantation
  • Microvascular invasion
  • Tumor recurrence

ASJC Scopus subject areas

  • Transplantation

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