Abstract
CD4 T-cell-specific memory antiviral responses to human immunodeficiency virus type 1 (HIV-1) and cytomegalovirus (CMV) were investigated in 16 patients with documented primary HIV-1 infection (4 of the 16 subjects also had primary CMV infection) and compared with those observed in patients with chronic HIV-1 and CMV coinfection. Virus-specific memory CD4 T cells were characterized on the basis of the expression of the chemokine receptor CCR7. HIV-1- and CMV-specific interferon-γ-secreting CD4 T cells were detected in patients with primary and chronic HIV-1 and CMV coinfection and were mostly contained in the cell population lacking expression of CCR7. The magnitude of the primary CMV-specific CD4 T-cell response was significantly greater than that of chronic CMV infection, whereas there were no differences between primary and chronic HIV-1-specific CD4 T-cell responses. A substantial proportion of CD4+CCR7- T cells were infected with HIV-1. These results advance the characterization of antiviral memory CD4 T-cell response and the delineation of the potential mechanisms that likely prevent the generation of a robust CD4 T-cell immune response during primary infection.
| Original language | English |
|---|---|
| Pages (from-to) | 1381-1387 |
| Number of pages | 7 |
| Journal | Blood |
| Volume | 100 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 15 2002 |
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ASJC Scopus subject areas
- Hematology
Cite this
Analysis of HIV-1- and CMV-specific memory CD4 T-cell responses during primary and chronic infection. / Harari, Alexandre; Paolo Rizzardi, G.; Ellefsen, Kim; Ciuffreda, Donatella; Champagne, Patrick; Bart, Pierre Alexandre; Kaufmann, Daniel; Telenti, Amalio; Sahli, Roland; Tambussi, Giuseppe; Kaiser, Laurent; Lazzarin, Adriano; Perrin, Luc; Pantaleo, Giuseppe.
In: Blood, Vol. 100, No. 4, 15.08.2002, p. 1381-1387.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of HIV-1- and CMV-specific memory CD4 T-cell responses during primary and chronic infection
AU - Harari, Alexandre
AU - Paolo Rizzardi, G.
AU - Ellefsen, Kim
AU - Ciuffreda, Donatella
AU - Champagne, Patrick
AU - Bart, Pierre Alexandre
AU - Kaufmann, Daniel
AU - Telenti, Amalio
AU - Sahli, Roland
AU - Tambussi, Giuseppe
AU - Kaiser, Laurent
AU - Lazzarin, Adriano
AU - Perrin, Luc
AU - Pantaleo, Giuseppe
PY - 2002/8/15
Y1 - 2002/8/15
N2 - CD4 T-cell-specific memory antiviral responses to human immunodeficiency virus type 1 (HIV-1) and cytomegalovirus (CMV) were investigated in 16 patients with documented primary HIV-1 infection (4 of the 16 subjects also had primary CMV infection) and compared with those observed in patients with chronic HIV-1 and CMV coinfection. Virus-specific memory CD4 T cells were characterized on the basis of the expression of the chemokine receptor CCR7. HIV-1- and CMV-specific interferon-γ-secreting CD4 T cells were detected in patients with primary and chronic HIV-1 and CMV coinfection and were mostly contained in the cell population lacking expression of CCR7. The magnitude of the primary CMV-specific CD4 T-cell response was significantly greater than that of chronic CMV infection, whereas there were no differences between primary and chronic HIV-1-specific CD4 T-cell responses. A substantial proportion of CD4+CCR7- T cells were infected with HIV-1. These results advance the characterization of antiviral memory CD4 T-cell response and the delineation of the potential mechanisms that likely prevent the generation of a robust CD4 T-cell immune response during primary infection.
AB - CD4 T-cell-specific memory antiviral responses to human immunodeficiency virus type 1 (HIV-1) and cytomegalovirus (CMV) were investigated in 16 patients with documented primary HIV-1 infection (4 of the 16 subjects also had primary CMV infection) and compared with those observed in patients with chronic HIV-1 and CMV coinfection. Virus-specific memory CD4 T cells were characterized on the basis of the expression of the chemokine receptor CCR7. HIV-1- and CMV-specific interferon-γ-secreting CD4 T cells were detected in patients with primary and chronic HIV-1 and CMV coinfection and were mostly contained in the cell population lacking expression of CCR7. The magnitude of the primary CMV-specific CD4 T-cell response was significantly greater than that of chronic CMV infection, whereas there were no differences between primary and chronic HIV-1-specific CD4 T-cell responses. A substantial proportion of CD4+CCR7- T cells were infected with HIV-1. These results advance the characterization of antiviral memory CD4 T-cell response and the delineation of the potential mechanisms that likely prevent the generation of a robust CD4 T-cell immune response during primary infection.
UR - http://www.scopus.com/inward/record.url?scp=0037103201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037103201&partnerID=8YFLogxK
U2 - 10.1182/blood-2001-11-0080
DO - 10.1182/blood-2001-11-0080
M3 - Article
C2 - 12149221
AN - SCOPUS:0037103201
VL - 100
SP - 1381
EP - 1387
JO - Blood
JF - Blood
SN - 0006-4971
IS - 4
ER -