Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians

Letizia Scola; Domenico Lio; Antonio Crivello; Giuseppina Candore; Giusi Irma Forte; Giuseppina Colonna-Romano; Mario Giovanni Pes; Ciriaco Carru; Luigi Ferrucci; Luca Deiana; Giovannella Baggio; Claudio Franceschi; Calogero Caruso

doi:10.1089/rej.2006.9.157

Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians

Letizia Scola, Domenico Lio, Antonio Crivello, Giuseppina Candore, Giusi Irma Forte, Giuseppina Colonna-Romano, Mario Giovanni Pes, Ciriaco Carru, Luigi Ferrucci, Luca Deiana, Giovannella Baggio, Claudio Franceschi, Calogero Caruso

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Human leukocyte antigen (HLA) alleles, regulating type and intensity of the immune response, might influence life expectancy. In previous case-control studies the authors have demonstrated that both HLA-DR and -DQ alleles are not associated with longevity in the Sardinian population. On the other hand, association studies are subjected (as part of the homogeneity of the population in terms of geographic origin) to a number of possible confounding factors. Therefore, the authors typed the HLA-DQA1 and HLA-DQB1 alleles in 24 sibs (age range 85 to 97) of 17 centenarians by PCR-SSP. Sib pair analysis showed non-significant differences between the observed and expected percentage of DQA* or DQB1* allele sharing. Therefore, these data strengthen the view that class II HLA genes have a marginal effect, if any, on the complex longevity trait.

Original language	English
Pages (from-to)	157-160
Number of pages	4
Journal	Rejuvenation Research
Volume	9
Issue number	1
DOIs	https://doi.org/10.1089/rej.2006.9.157
Publication status	Published - Mar 2006

ASJC Scopus subject areas

Ageing

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Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians. / Scola, Letizia; Lio, Domenico; Crivello, Antonio; Candore, Giuseppina; Forte, Giusi Irma; Colonna-Romano, Giuseppina; Pes, Mario Giovanni; Carru, Ciriaco; Ferrucci, Luigi; Deiana, Luca; Baggio, Giovannella; Franceschi, Claudio; Caruso, Calogero.

In: Rejuvenation Research, Vol. 9, No. 1, 03.2006, p. 157-160.

Research output: Contribution to journal › Article › peer-review

Scola, Letizia ; Lio, Domenico ; Crivello, Antonio ; Candore, Giuseppina ; Forte, Giusi Irma ; Colonna-Romano, Giuseppina ; Pes, Mario Giovanni ; Carru, Ciriaco ; Ferrucci, Luigi ; Deiana, Luca ; Baggio, Giovannella ; Franceschi, Claudio ; Caruso, Calogero. / Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians. In: Rejuvenation Research. 2006 ; Vol. 9, No. 1. pp. 157-160.

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abstract = "Human leukocyte antigen (HLA) alleles, regulating type and intensity of the immune response, might influence life expectancy. In previous case-control studies the authors have demonstrated that both HLA-DR and -DQ alleles are not associated with longevity in the Sardinian population. On the other hand, association studies are subjected (as part of the homogeneity of the population in terms of geographic origin) to a number of possible confounding factors. Therefore, the authors typed the HLA-DQA1 and HLA-DQB1 alleles in 24 sibs (age range 85 to 97) of 17 centenarians by PCR-SSP. Sib pair analysis showed non-significant differences between the observed and expected percentage of DQA* or DQB1* allele sharing. Therefore, these data strengthen the view that class II HLA genes have a marginal effect, if any, on the complex longevity trait.",

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