TY - JOUR
T1 - Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians
AU - Scola, Letizia
AU - Lio, Domenico
AU - Crivello, Antonio
AU - Candore, Giuseppina
AU - Forte, Giusi Irma
AU - Colonna-Romano, Giuseppina
AU - Pes, Mario Giovanni
AU - Carru, Ciriaco
AU - Ferrucci, Luigi
AU - Deiana, Luca
AU - Baggio, Giovannella
AU - Franceschi, Claudio
AU - Caruso, Calogero
PY - 2006/3
Y1 - 2006/3
N2 - Human leukocyte antigen (HLA) alleles, regulating type and intensity of the immune response, might influence life expectancy. In previous case-control studies the authors have demonstrated that both HLA-DR and -DQ alleles are not associated with longevity in the Sardinian population. On the other hand, association studies are subjected (as part of the homogeneity of the population in terms of geographic origin) to a number of possible confounding factors. Therefore, the authors typed the HLA-DQA1 and HLA-DQB1 alleles in 24 sibs (age range 85 to 97) of 17 centenarians by PCR-SSP. Sib pair analysis showed non-significant differences between the observed and expected percentage of DQA* or DQB1* allele sharing. Therefore, these data strengthen the view that class II HLA genes have a marginal effect, if any, on the complex longevity trait.
AB - Human leukocyte antigen (HLA) alleles, regulating type and intensity of the immune response, might influence life expectancy. In previous case-control studies the authors have demonstrated that both HLA-DR and -DQ alleles are not associated with longevity in the Sardinian population. On the other hand, association studies are subjected (as part of the homogeneity of the population in terms of geographic origin) to a number of possible confounding factors. Therefore, the authors typed the HLA-DQA1 and HLA-DQB1 alleles in 24 sibs (age range 85 to 97) of 17 centenarians by PCR-SSP. Sib pair analysis showed non-significant differences between the observed and expected percentage of DQA* or DQB1* allele sharing. Therefore, these data strengthen the view that class II HLA genes have a marginal effect, if any, on the complex longevity trait.
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U2 - 10.1089/rej.2006.9.157
DO - 10.1089/rej.2006.9.157
M3 - Article
C2 - 16608414
AN - SCOPUS:33646051953
VL - 9
SP - 157
EP - 160
JO - Rejuvenation Research
JF - Rejuvenation Research
SN - 1549-1684
IS - 1
ER -