Analysis of human herpesvirus type 8 infection in AIDS-related and AIDS- unrelated primary central nervous system lymphoma

Gianluca Gaidano, Daniela Capello, Cristina Pastore, Andrea Antinori, Annunziata Gloghini, Antonino Carbone, Luigi Maria Larocca, Giuseppe Saglio

Research output: Contribution to journalArticlepeer-review

Abstract

Human herpesvirus type 8 (HHV-8) has been proposed as a pathogenetic factor for immunosuppression-associated primary central nervous system lymphoma (PCNSL). To verify this hypothesis, HHV-8 infection was investigated in 31 persons with PCNSL (16 AIDS-related, 15 AIDS-unrelated) and in 30 persons with systemic B cell non-Hodgkin's lymphomas (B-NHL; 15 AIDS-related, 15 AIDS-unrelated). All subjects with PCNSL scored negative by single-step polymerase chain reaction (PER), suggesting a tumor virus load of <100 vital copies/200,000 human haploid genome equivalents (HHGE). By applying Poisson assumptions to nested PeR, 16 of 31 persons with PCNSL were devoid of HHV-8 sequences: 1 subject with AIDS and PCNSL had 1-100 viral copies/200,000 HHGE, and 14 with PCNSL had

Original languageEnglish
Pages (from-to)1193-1197
Number of pages5
JournalJournal of Infectious Diseases
Volume175
Issue number5
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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