Analysis of immune, microbiota and metabolome maturation in infants in a clinical trial of Lactobacillus paracasei CBA L74-fermented formula

Paola Roggero; Nadia Liotto; Chiara Pozzi; Daniele Braga; Jacopo Troisi; Camilla Menis; Maria Lorella Giannì; Roberto Berni Canani; Lorella Paparo; Rita Nocerino; Andrea Budelli; Fabio Mosca; Maria Rescigno

doi:10.1038/s41467-020-16582-1

Analysis of immune, microbiota and metabolome maturation in infants in a clinical trial of Lactobacillus paracasei CBA L74-fermented formula

Paola Roggero, Nadia Liotto, Chiara Pozzi, Daniele Braga, Jacopo Troisi, Camilla Menis, Maria Lorella Giannì, Roberto Berni Canani, Lorella Paparo, Rita Nocerino, Andrea Budelli, Fabio Mosca, Maria Rescigno

Research output: Contribution to journal › Article › peer-review

Abstract

Mother’s milk is the best choice for infants nutrition, however when it is not available or insufficient to satisfy the needs of the infant, formula is proposed as an effective substitute. Here, we report the results of a randomized controlled clinical trial (NCT03637894) designed to evaluate the effects of two different dietary regimens (standard formula and Lactobacillus paracasei CBA L74-fermented formula) versus breastfeeding (reference group) on immune defense mechanisms (primary endpoint: secretory IgA, antimicrobial peptides), the microbiota and its metabolome (secondary outcomes), in healthy full term infants according to the type of delivery (n = 13/group). We show that the fermented formula, safe and well tolerated, induces an increase in secretory IgA (but not in antimicrobial peptides) and reduces the diversity of the microbiota, similarly, but not as much as, breastmilk. Metabolome analysis allowed us to distinguish subjects based on their dietary regimen and mode of delivery. Together, these results suggest that a fermented formula favors the maturation of the immune system, microbiota and metabolome.

Original language	English
Article number	2703
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-16582-1
Publication status	Published - Dec 1 2020

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

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Roggero, P., Liotto, N., Pozzi, C., Braga, D., Troisi, J., Menis, C., Giannì, M. L., Berni Canani, R., Paparo, L., Nocerino, R., Budelli, A., Mosca, F., & Rescigno, M. (2020). Analysis of immune, microbiota and metabolome maturation in infants in a clinical trial of Lactobacillus paracasei CBA L74-fermented formula. Nature Communications, 11(1), [2703]. https://doi.org/10.1038/s41467-020-16582-1

Roggero, P, Liotto, N , Pozzi, C , Braga, D, Troisi, J, Menis, C, Giannì, ML, Berni Canani, R, Paparo, L, Nocerino, R, Budelli, A, Mosca, F & Rescigno, M 2020, 'Analysis of immune, microbiota and metabolome maturation in infants in a clinical trial of Lactobacillus paracasei CBA L74-fermented formula', Nature Communications, vol. 11, no. 1, 2703. https://doi.org/10.1038/s41467-020-16582-1

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Analysis of immune, microbiota and metabolome maturation in infants in a clinical trial of Lactobacillus paracasei CBA L74-fermented formula

Abstract

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