Analysis of intronic conserved elements indicates that functional complexity might represent a major source of negative selection on non-coding sequences

Research output: Contribution to journalArticle

Abstract

The non-coding portion of human genome is punctuated by a large number of multispecies conserved sequence (MCS) elements with largely unknown function. We demonstrate that MCSs are unevenly distributed in human introns with the majority of relatively short introns (

Original languageEnglish
Pages (from-to)2533-2546
Number of pages14
JournalHuman Molecular Genetics
Volume14
Issue number17
DOIs
Publication statusPublished - Sep 1 2005

Keywords

  • Adrenergic
  • Beta
  • Heart failure
  • Lymphocytes
  • Prognosis
  • Receptors
  • Signal transduction

ASJC Scopus subject areas

  • Genetics

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