Analysis of lymphocyte phenotype and T cell receptor genotype in Felty's syndrome

R. Meliconi, G. H. Kingsley, C. Pitzalis, L. Sakkas, G. S. Panayi

Research output: Contribution to journalArticlepeer-review

Abstract

Natural killer (NK) cells and CD3+ large granular lymphocytes (LGL) were investigated in patients with Felty's syndrome (FS), rheumatoid arthritis (RA) and healthy controls. In most patients with FS, NK cell number and activity were decreased. CD3+ LGL were unchanged. However, in one patient a marked expansion of CD3 - CD16+ CD56+ (NK) cells was seen and in a second, an expansion of CD3+ LGL. In FS there was also an increase in HLA-DR+ and CD8+ but not γδ+ T cells. Three of 11 patients with FS studied demonstrated a dominant rearrangement of the T cell receptor β gene constant region consistent with oligoclonal T cell expansion.

Original languageEnglish
Pages (from-to)1058-1064
Number of pages7
JournalJournal of Rheumatology
Volume19
Issue number7
Publication statusPublished - 1992

Keywords

  • Felty's syndrome
  • large granular lymphocytes
  • natural killer cells
  • T cell receptor gene rearrangement

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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