Abstract
Aim: Mink protein, a β-subunit of Iks potassium channels modulate cardiac cellular electrophysiology, and experimental data demonstrated that NO is involved in cardiac vagal activity and in the inhibition of sympathetic activity. We evaluated the role of eNOS -786T>C, 894G>T, 4a/4b and of minK S38G polymorphisms as predisposing factors to non-valvular atrial fibrillation (NVAF). Methods and results: We studied 331 consecutive patients with documented NVAF and in 441 control subjects, comparable for age and gender. A significant difference in allele frequencies between patients and controls for minK S38G and eNOS -786T>C, but not for eNOS 894G>T and 4a/4b polymorphisms, was observed. The minK 38G allele was significantly associated with susceptibility to NVAF at both univariate and multivariable analysis, according to dominant and recessive genetic model (multivariable analysis, dominant: OR=1.73, P=0.004 and recessive: OR=1.59, P=0.006). The eNOS -786C allele weakly influenced NVAF at univariate analysis, according to the dominant model (OR=1.50, P=0.01). The contemporary presence of minK 38G and eNOS -786C alleles increased the predisposition to NVAF, after adjustment with cardiovascular risk factors (OR minK 38G*eNOS -786C=2.11, P
| Original language | English |
|---|---|
| Pages (from-to) | 1712-1718 |
| Number of pages | 7 |
| Journal | European Heart Journal |
| Volume | 27 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - Jul 2006 |
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Keywords
- 4a/4b polymorphisms
- 894G>T
- eNOS -786T>C
- minK S38G polymorphism
- Non-valvular atrial fibrillation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation. / Fatini, Cinzia; Sticchi, Elena; Genuardi, Maurizio; Sofi, Francesco; Gensini, Francesca; Gori, Anna Maria; Lenti, Meri; Michelucci, Antonio; Abbate, Rosanna; Gensini, Gian Franco.
In: European Heart Journal, Vol. 27, No. 14, 07.2006, p. 1712-1718.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation
AU - Fatini, Cinzia
AU - Sticchi, Elena
AU - Genuardi, Maurizio
AU - Sofi, Francesco
AU - Gensini, Francesca
AU - Gori, Anna Maria
AU - Lenti, Meri
AU - Michelucci, Antonio
AU - Abbate, Rosanna
AU - Gensini, Gian Franco
PY - 2006/7
Y1 - 2006/7
N2 - Aim: Mink protein, a β-subunit of Iks potassium channels modulate cardiac cellular electrophysiology, and experimental data demonstrated that NO is involved in cardiac vagal activity and in the inhibition of sympathetic activity. We evaluated the role of eNOS -786T>C, 894G>T, 4a/4b and of minK S38G polymorphisms as predisposing factors to non-valvular atrial fibrillation (NVAF). Methods and results: We studied 331 consecutive patients with documented NVAF and in 441 control subjects, comparable for age and gender. A significant difference in allele frequencies between patients and controls for minK S38G and eNOS -786T>C, but not for eNOS 894G>T and 4a/4b polymorphisms, was observed. The minK 38G allele was significantly associated with susceptibility to NVAF at both univariate and multivariable analysis, according to dominant and recessive genetic model (multivariable analysis, dominant: OR=1.73, P=0.004 and recessive: OR=1.59, P=0.006). The eNOS -786C allele weakly influenced NVAF at univariate analysis, according to the dominant model (OR=1.50, P=0.01). The contemporary presence of minK 38G and eNOS -786C alleles increased the predisposition to NVAF, after adjustment with cardiovascular risk factors (OR minK 38G*eNOS -786C=2.11, P
AB - Aim: Mink protein, a β-subunit of Iks potassium channels modulate cardiac cellular electrophysiology, and experimental data demonstrated that NO is involved in cardiac vagal activity and in the inhibition of sympathetic activity. We evaluated the role of eNOS -786T>C, 894G>T, 4a/4b and of minK S38G polymorphisms as predisposing factors to non-valvular atrial fibrillation (NVAF). Methods and results: We studied 331 consecutive patients with documented NVAF and in 441 control subjects, comparable for age and gender. A significant difference in allele frequencies between patients and controls for minK S38G and eNOS -786T>C, but not for eNOS 894G>T and 4a/4b polymorphisms, was observed. The minK 38G allele was significantly associated with susceptibility to NVAF at both univariate and multivariable analysis, according to dominant and recessive genetic model (multivariable analysis, dominant: OR=1.73, P=0.004 and recessive: OR=1.59, P=0.006). The eNOS -786C allele weakly influenced NVAF at univariate analysis, according to the dominant model (OR=1.50, P=0.01). The contemporary presence of minK 38G and eNOS -786C alleles increased the predisposition to NVAF, after adjustment with cardiovascular risk factors (OR minK 38G*eNOS -786C=2.11, P
KW - 4a/4b polymorphisms
KW - 894G>T
KW - eNOS -786T>C
KW - minK S38G polymorphism
KW - Non-valvular atrial fibrillation
UR - http://www.scopus.com/inward/record.url?scp=33745801021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745801021&partnerID=8YFLogxK
U2 - 10.1093/eurheartj/ehl087
DO - 10.1093/eurheartj/ehl087
M3 - Article
C2 - 16760206
AN - SCOPUS:33745801021
VL - 27
SP - 1712
EP - 1718
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 14
ER -