Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation

Cinzia Fatini, Elena Sticchi, Maurizio Genuardi, Francesco Sofi, Francesca Gensini, Anna Maria Gori, Meri Lenti, Antonio Michelucci, Rosanna Abbate, Gian Franco Gensini

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Aim: Mink protein, a β-subunit of Iks potassium channels modulate cardiac cellular electrophysiology, and experimental data demonstrated that NO is involved in cardiac vagal activity and in the inhibition of sympathetic activity. We evaluated the role of eNOS -786T>C, 894G>T, 4a/4b and of minK S38G polymorphisms as predisposing factors to non-valvular atrial fibrillation (NVAF). Methods and results: We studied 331 consecutive patients with documented NVAF and in 441 control subjects, comparable for age and gender. A significant difference in allele frequencies between patients and controls for minK S38G and eNOS -786T>C, but not for eNOS 894G>T and 4a/4b polymorphisms, was observed. The minK 38G allele was significantly associated with susceptibility to NVAF at both univariate and multivariable analysis, according to dominant and recessive genetic model (multivariable analysis, dominant: OR=1.73, P=0.004 and recessive: OR=1.59, P=0.006). The eNOS -786C allele weakly influenced NVAF at univariate analysis, according to the dominant model (OR=1.50, P=0.01). The contemporary presence of minK 38G and eNOS -786C alleles increased the predisposition to NVAF, after adjustment with cardiovascular risk factors (OR minK 38G*eNOS -786C=2.11, P

Original languageEnglish
Pages (from-to)1712-1718
Number of pages7
JournalEuropean Heart Journal
Volume27
Issue number14
DOIs
Publication statusPublished - Jul 2006

Fingerprint

Mink
Atrial Fibrillation
Genes
Alleles
Cardiac Electrophysiology
Potassium Channels
Genetic Models
Protein Subunits
Gene Frequency
Causality

Keywords

  • 4a/4b polymorphisms
  • 894G>T
  • eNOS -786T>C
  • minK S38G polymorphism
  • Non-valvular atrial fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation. / Fatini, Cinzia; Sticchi, Elena; Genuardi, Maurizio; Sofi, Francesco; Gensini, Francesca; Gori, Anna Maria; Lenti, Meri; Michelucci, Antonio; Abbate, Rosanna; Gensini, Gian Franco.

In: European Heart Journal, Vol. 27, No. 14, 07.2006, p. 1712-1718.

Research output: Contribution to journalArticle

Fatini, C, Sticchi, E, Genuardi, M, Sofi, F, Gensini, F, Gori, AM, Lenti, M, Michelucci, A, Abbate, R & Gensini, GF 2006, 'Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation', European Heart Journal, vol. 27, no. 14, pp. 1712-1718. https://doi.org/10.1093/eurheartj/ehl087
Fatini, Cinzia ; Sticchi, Elena ; Genuardi, Maurizio ; Sofi, Francesco ; Gensini, Francesca ; Gori, Anna Maria ; Lenti, Meri ; Michelucci, Antonio ; Abbate, Rosanna ; Gensini, Gian Franco. / Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation. In: European Heart Journal. 2006 ; Vol. 27, No. 14. pp. 1712-1718.
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AU - Sticchi, Elena

AU - Genuardi, Maurizio

AU - Sofi, Francesco

AU - Gensini, Francesca

AU - Gori, Anna Maria

AU - Lenti, Meri

AU - Michelucci, Antonio

AU - Abbate, Rosanna

AU - Gensini, Gian Franco

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AB - Aim: Mink protein, a β-subunit of Iks potassium channels modulate cardiac cellular electrophysiology, and experimental data demonstrated that NO is involved in cardiac vagal activity and in the inhibition of sympathetic activity. We evaluated the role of eNOS -786T>C, 894G>T, 4a/4b and of minK S38G polymorphisms as predisposing factors to non-valvular atrial fibrillation (NVAF). Methods and results: We studied 331 consecutive patients with documented NVAF and in 441 control subjects, comparable for age and gender. A significant difference in allele frequencies between patients and controls for minK S38G and eNOS -786T>C, but not for eNOS 894G>T and 4a/4b polymorphisms, was observed. The minK 38G allele was significantly associated with susceptibility to NVAF at both univariate and multivariable analysis, according to dominant and recessive genetic model (multivariable analysis, dominant: OR=1.73, P=0.004 and recessive: OR=1.59, P=0.006). The eNOS -786C allele weakly influenced NVAF at univariate analysis, according to the dominant model (OR=1.50, P=0.01). The contemporary presence of minK 38G and eNOS -786C alleles increased the predisposition to NVAF, after adjustment with cardiovascular risk factors (OR minK 38G*eNOS -786C=2.11, P

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