Analysis of monoamine oxidase A (MAO-A) promoter polymorphism in male heroin-dependent subjects

Behavioural and personality correlates

G. Gerra, L. Garofano, S. Bosari, C. Pellegrini, A. Zaimovic, G. Moi, M. Bussandri, A. Moi, F. Brambilla, A. Mameli, M. Pizzamiglio, C. Donnini

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The promoter of the monoamine oxidase A (MAO-A) gene was analysed to test whether length variation of the repeat polymorphism contributes to variation in individual vulnerability to aggressive-criminal behaviour, and liability to heroin dependence. The repeat number of the MAO-A polymorphism was assessed in 199 male subjects of Italian descent, a sample comprising 95 healthy subjects and 104 heroin-dependent subjects including 52 addicted individuals with violent behaviour and antisocial personality disorder. The frequency of the low-activity 3-repeat allele was significantly higher in violent offenders among heroin addicts, compared to addicted individuals without antisocial behaviour (34.6 vs. 15.4%; p

Original languageEnglish
Pages (from-to)611-621
Number of pages11
JournalJournal of Neural Transmission
Volume111
Issue number5
DOIs
Publication statusPublished - May 2004

Fingerprint

Heroin
Monoamine Oxidase
Personality
Heroin Dependence
Antisocial Personality Disorder
Healthy Volunteers
Alleles
Genes
Criminal Behavior

Keywords

  • Aggressiveness
  • Antisocial behaviour
  • Heroin dependence
  • MAO-A gene
  • Polymorphism
  • Promoter
  • Violent offenders

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Analysis of monoamine oxidase A (MAO-A) promoter polymorphism in male heroin-dependent subjects : Behavioural and personality correlates. / Gerra, G.; Garofano, L.; Bosari, S.; Pellegrini, C.; Zaimovic, A.; Moi, G.; Bussandri, M.; Moi, A.; Brambilla, F.; Mameli, A.; Pizzamiglio, M.; Donnini, C.

In: Journal of Neural Transmission, Vol. 111, No. 5, 05.2004, p. 611-621.

Research output: Contribution to journalArticle

Gerra, G, Garofano, L, Bosari, S, Pellegrini, C, Zaimovic, A, Moi, G, Bussandri, M, Moi, A, Brambilla, F, Mameli, A, Pizzamiglio, M & Donnini, C 2004, 'Analysis of monoamine oxidase A (MAO-A) promoter polymorphism in male heroin-dependent subjects: Behavioural and personality correlates', Journal of Neural Transmission, vol. 111, no. 5, pp. 611-621. https://doi.org/10.1007/s00702-004-0129-8
Gerra, G. ; Garofano, L. ; Bosari, S. ; Pellegrini, C. ; Zaimovic, A. ; Moi, G. ; Bussandri, M. ; Moi, A. ; Brambilla, F. ; Mameli, A. ; Pizzamiglio, M. ; Donnini, C. / Analysis of monoamine oxidase A (MAO-A) promoter polymorphism in male heroin-dependent subjects : Behavioural and personality correlates. In: Journal of Neural Transmission. 2004 ; Vol. 111, No. 5. pp. 611-621.
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