Analysis of monoamine oxidase A (MAO-A) promoter polymorphism in male heroin-dependent subjects: Behavioural and personality correlates

G. Gerra, L. Garofano, S. Bosari, C. Pellegrini, A. Zaimovic, G. Moi, M. Bussandri, A. Moi, F. Brambilla, A. Mameli, M. Pizzamiglio, C. Donnini

Research output: Contribution to journalArticle

Abstract

The promoter of the monoamine oxidase A (MAO-A) gene was analysed to test whether length variation of the repeat polymorphism contributes to variation in individual vulnerability to aggressive-criminal behaviour, and liability to heroin dependence. The repeat number of the MAO-A polymorphism was assessed in 199 male subjects of Italian descent, a sample comprising 95 healthy subjects and 104 heroin-dependent subjects including 52 addicted individuals with violent behaviour and antisocial personality disorder. The frequency of the low-activity 3-repeat allele was significantly higher in violent offenders among heroin addicts, compared to addicted individuals without antisocial behaviour (34.6 vs. 15.4%; p

Original languageEnglish
Pages (from-to)611-621
Number of pages11
JournalJournal of Neural Transmission
Volume111
Issue number5
DOIs
Publication statusPublished - May 2004

Keywords

  • Aggressiveness
  • Antisocial behaviour
  • Heroin dependence
  • MAO-A gene
  • Polymorphism
  • Promoter
  • Violent offenders

ASJC Scopus subject areas

  • Neuroscience(all)

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    Gerra, G., Garofano, L., Bosari, S., Pellegrini, C., Zaimovic, A., Moi, G., Bussandri, M., Moi, A., Brambilla, F., Mameli, A., Pizzamiglio, M., & Donnini, C. (2004). Analysis of monoamine oxidase A (MAO-A) promoter polymorphism in male heroin-dependent subjects: Behavioural and personality correlates. Journal of Neural Transmission, 111(5), 611-621. https://doi.org/10.1007/s00702-004-0129-8