Abstract
ABSTARCT: Genome-wide association studies pinpointed common variants in or near the MTNR1B gene encoding MT2 melatonin receptor to be strongly associated with fasting glucose levels. IRS2 gene polymorphisms impact insulin resistance and epicardial fat (EF) thickness, which in turn is correlated with visceral adiposity, cognitive ability and risk for metabolic plus cardiovascular disease. We aimed to discover the interactions between MTNR1B and IRS2 gene polymorphisms, insulin sensitivity, EF thickness and cognitive performance in the elderly. In 60 subjects aged 60 years and older, we evaluated five single nucleotide polymorphisms (SNPs) within the MTNR1B locus (rs10830962, rs4753426, rs12804291, rs10830963, rs3781638), the Gly1057Asp variant of IRS2 gene (rs1805097), biochemical parameters, cognitive performance by the Mini Mental State Examination (MMSE) and EF thickness by transthoracic echocardiography. We found that MTNR1B and IRS2 gene variants impacted EF thickness, lipid profile and glucose homeostasis. IRS2 but not MTNR1B variants impacted MMSE scores. In conclusion, MTNR1B SNPs interact with IRS2 gene variant, correlate with the amount of epicardial adipose tissue and impact glucose homeostasis and lipid profile influencing cardiometabolic risk.
| Original language | English |
|---|---|
| Pages (from-to) | 1083-1093 |
| Number of pages | 11 |
| Journal | Chronobiology International |
| Volume | 34 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Sep 14 2017 |
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Keywords
- aging
- cognition
- epicardial fat
- IRS2
- Melatonin
- metabolism
- MTNR1B
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Analysis of MTNR1B gene polymorphisms in relationship with IRS2 gene variants, epicardial fat thickness, glucose homeostasis and cognitive performance in the elderly. / Mazzoccoli, Gianluigi; Dagostino, Mariangela Pia; Paroni, Giulia; Seripa, Davide; Ciccone, Filomena; Addante, Filomena; Favuzzi, Giovanni; Grandone, Elvira; Avola, Roberto; Mazza, Tommaso; Fusilli, Caterina; Greco, Antonio; De Cosmo, Salvatore.
In: Chronobiology International, Vol. 34, No. 8, 14.09.2017, p. 1083-1093.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of MTNR1B gene polymorphisms in relationship with IRS2 gene variants, epicardial fat thickness, glucose homeostasis and cognitive performance in the elderly
AU - Mazzoccoli, Gianluigi
AU - Dagostino, Mariangela Pia
AU - Paroni, Giulia
AU - Seripa, Davide
AU - Ciccone, Filomena
AU - Addante, Filomena
AU - Favuzzi, Giovanni
AU - Grandone, Elvira
AU - Avola, Roberto
AU - Mazza, Tommaso
AU - Fusilli, Caterina
AU - Greco, Antonio
AU - De Cosmo, Salvatore
PY - 2017/9/14
Y1 - 2017/9/14
N2 - ABSTARCT: Genome-wide association studies pinpointed common variants in or near the MTNR1B gene encoding MT2 melatonin receptor to be strongly associated with fasting glucose levels. IRS2 gene polymorphisms impact insulin resistance and epicardial fat (EF) thickness, which in turn is correlated with visceral adiposity, cognitive ability and risk for metabolic plus cardiovascular disease. We aimed to discover the interactions between MTNR1B and IRS2 gene polymorphisms, insulin sensitivity, EF thickness and cognitive performance in the elderly. In 60 subjects aged 60 years and older, we evaluated five single nucleotide polymorphisms (SNPs) within the MTNR1B locus (rs10830962, rs4753426, rs12804291, rs10830963, rs3781638), the Gly1057Asp variant of IRS2 gene (rs1805097), biochemical parameters, cognitive performance by the Mini Mental State Examination (MMSE) and EF thickness by transthoracic echocardiography. We found that MTNR1B and IRS2 gene variants impacted EF thickness, lipid profile and glucose homeostasis. IRS2 but not MTNR1B variants impacted MMSE scores. In conclusion, MTNR1B SNPs interact with IRS2 gene variant, correlate with the amount of epicardial adipose tissue and impact glucose homeostasis and lipid profile influencing cardiometabolic risk.
AB - ABSTARCT: Genome-wide association studies pinpointed common variants in or near the MTNR1B gene encoding MT2 melatonin receptor to be strongly associated with fasting glucose levels. IRS2 gene polymorphisms impact insulin resistance and epicardial fat (EF) thickness, which in turn is correlated with visceral adiposity, cognitive ability and risk for metabolic plus cardiovascular disease. We aimed to discover the interactions between MTNR1B and IRS2 gene polymorphisms, insulin sensitivity, EF thickness and cognitive performance in the elderly. In 60 subjects aged 60 years and older, we evaluated five single nucleotide polymorphisms (SNPs) within the MTNR1B locus (rs10830962, rs4753426, rs12804291, rs10830963, rs3781638), the Gly1057Asp variant of IRS2 gene (rs1805097), biochemical parameters, cognitive performance by the Mini Mental State Examination (MMSE) and EF thickness by transthoracic echocardiography. We found that MTNR1B and IRS2 gene variants impacted EF thickness, lipid profile and glucose homeostasis. IRS2 but not MTNR1B variants impacted MMSE scores. In conclusion, MTNR1B SNPs interact with IRS2 gene variant, correlate with the amount of epicardial adipose tissue and impact glucose homeostasis and lipid profile influencing cardiometabolic risk.
KW - aging
KW - cognition
KW - epicardial fat
KW - IRS2
KW - Melatonin
KW - metabolism
KW - MTNR1B
UR - http://www.scopus.com/inward/record.url?scp=85023763592&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85023763592&partnerID=8YFLogxK
U2 - 10.1080/07420528.2017.1340894
DO - 10.1080/07420528.2017.1340894
M3 - Article
AN - SCOPUS:85023763592
VL - 34
SP - 1083
EP - 1093
JO - Chronobiology International
JF - Chronobiology International
SN - 0742-0528
IS - 8
ER -