Analysis of MTNR1B gene polymorphisms in relationship with IRS2 gene variants, epicardial fat thickness, glucose homeostasis and cognitive performance in the elderly

Gianluigi Mazzoccoli, Mariangela Pia Dagostino, Giulia Paroni, Davide Seripa, Filomena Ciccone, Filomena Addante, Giovanni Favuzzi, Elvira Grandone, Roberto Avola, Tommaso Mazza, Caterina Fusilli, Antonio Greco, Salvatore De Cosmo

Research output: Contribution to journalArticlepeer-review

Abstract

ABSTARCT: Genome-wide association studies pinpointed common variants in or near the MTNR1B gene encoding MT2 melatonin receptor to be strongly associated with fasting glucose levels. IRS2 gene polymorphisms impact insulin resistance and epicardial fat (EF) thickness, which in turn is correlated with visceral adiposity, cognitive ability and risk for metabolic plus cardiovascular disease. We aimed to discover the interactions between MTNR1B and IRS2 gene polymorphisms, insulin sensitivity, EF thickness and cognitive performance in the elderly. In 60 subjects aged 60 years and older, we evaluated five single nucleotide polymorphisms (SNPs) within the MTNR1B locus (rs10830962, rs4753426, rs12804291, rs10830963, rs3781638), the Gly1057Asp variant of IRS2 gene (rs1805097), biochemical parameters, cognitive performance by the Mini Mental State Examination (MMSE) and EF thickness by transthoracic echocardiography. We found that MTNR1B and IRS2 gene variants impacted EF thickness, lipid profile and glucose homeostasis. IRS2 but not MTNR1B variants impacted MMSE scores. In conclusion, MTNR1B SNPs interact with IRS2 gene variant, correlate with the amount of epicardial adipose tissue and impact glucose homeostasis and lipid profile influencing cardiometabolic risk.

Original languageEnglish
Pages (from-to)1083-1093
Number of pages11
JournalChronobiology International
Volume34
Issue number8
DOIs
Publication statusPublished - Sep 14 2017

Keywords

  • aging
  • cognition
  • epicardial fat
  • IRS2
  • Melatonin
  • metabolism
  • MTNR1B

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Analysis of MTNR1B gene polymorphisms in relationship with IRS2 gene variants, epicardial fat thickness, glucose homeostasis and cognitive performance in the elderly'. Together they form a unique fingerprint.

Cite this