Abstract
Neuroretinal rim minimum distance band thickness is significantly lower in older subjects and African Americans compared to Caucasians. It is similar in both genders. Purpose: To evaluate the relationship between age, race, and gender with the neuroretinal rim using high-density spectral domain optical coherence tomography (SD-OCT) optic nerve volume scans of normal eyes. Methods: 256 normal subjects underwent Spectralis (Heidelberg Engineering, Heidelberg, Germany) SD-OCT optic nerve head volume scans. One eye was randomly selected and analyzed for each subject. Using custom-designed software, the neuroretinal rim minimum distance band (MDB) thickness was calculated from volume scans, and global and quadrant neuroretinal rim thickness values were determined. The MDB is a three-dimensional neuroretinal rim band comprised of the shortest distance between the internal limiting membrane (ILM) and the termination of the retinal pigment epithelium/Bruch's membrane (RPE/BM) complex. Multiple linear regression analysis was performed to determine the associations of age, race, and gender with neuroretinal rim MDB measurements. Results: The population was 57% female and 69% Caucasian with a mean age of 58.4±15.3 years. Mean MDB thickness in the normal population was 278.4±47.5μm. For this normal population, MDB thickness decreased by 0.84μm annually (P<0.001). African Americans had thinner MDBs compared to Caucasians (P=0.003). Males and females had similar MDB thickness values (P=0.349). Conclusions: Neuroretinal rim MDB thickness measurements decreased significantly with age. African Americans had thinner MDB neuroretinal rims than Caucasians.
| Original language | English |
|---|---|
| Journal | Journal of Glaucoma |
| DOIs | |
| Publication status | Accepted/In press - Jan 1 2019 |
| Externally published | Yes |
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Keywords
- neuroretinal rim
- optic nerve
- optical coherence tomography
ASJC Scopus subject areas
- Ophthalmology
Cite this
Analysis of Neuroretinal Rim by Age, Race, and Gender Using High-Density Three-Dimensional Spectral Domain Optical Coherence Tomography. / Antar, Hussein; Tsikata, Edem; Ratanawongphaibul, Kitiya; Zhang, Jing; Shieh, Eric; Lee, Ramon; Freeman, Madeline; Papadogeorgou, Georgia; Simavli, Huseyn; Que, Christian; Verticchio Vercellin, Alice C.; Khoueir, Ziad; De Boer, Johannes F.; Chen, Teresa C.
In: Journal of Glaucoma, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of Neuroretinal Rim by Age, Race, and Gender Using High-Density Three-Dimensional Spectral Domain Optical Coherence Tomography
AU - Antar, Hussein
AU - Tsikata, Edem
AU - Ratanawongphaibul, Kitiya
AU - Zhang, Jing
AU - Shieh, Eric
AU - Lee, Ramon
AU - Freeman, Madeline
AU - Papadogeorgou, Georgia
AU - Simavli, Huseyn
AU - Que, Christian
AU - Verticchio Vercellin, Alice C.
AU - Khoueir, Ziad
AU - De Boer, Johannes F.
AU - Chen, Teresa C.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Neuroretinal rim minimum distance band thickness is significantly lower in older subjects and African Americans compared to Caucasians. It is similar in both genders. Purpose: To evaluate the relationship between age, race, and gender with the neuroretinal rim using high-density spectral domain optical coherence tomography (SD-OCT) optic nerve volume scans of normal eyes. Methods: 256 normal subjects underwent Spectralis (Heidelberg Engineering, Heidelberg, Germany) SD-OCT optic nerve head volume scans. One eye was randomly selected and analyzed for each subject. Using custom-designed software, the neuroretinal rim minimum distance band (MDB) thickness was calculated from volume scans, and global and quadrant neuroretinal rim thickness values were determined. The MDB is a three-dimensional neuroretinal rim band comprised of the shortest distance between the internal limiting membrane (ILM) and the termination of the retinal pigment epithelium/Bruch's membrane (RPE/BM) complex. Multiple linear regression analysis was performed to determine the associations of age, race, and gender with neuroretinal rim MDB measurements. Results: The population was 57% female and 69% Caucasian with a mean age of 58.4±15.3 years. Mean MDB thickness in the normal population was 278.4±47.5μm. For this normal population, MDB thickness decreased by 0.84μm annually (P<0.001). African Americans had thinner MDBs compared to Caucasians (P=0.003). Males and females had similar MDB thickness values (P=0.349). Conclusions: Neuroretinal rim MDB thickness measurements decreased significantly with age. African Americans had thinner MDB neuroretinal rims than Caucasians.
AB - Neuroretinal rim minimum distance band thickness is significantly lower in older subjects and African Americans compared to Caucasians. It is similar in both genders. Purpose: To evaluate the relationship between age, race, and gender with the neuroretinal rim using high-density spectral domain optical coherence tomography (SD-OCT) optic nerve volume scans of normal eyes. Methods: 256 normal subjects underwent Spectralis (Heidelberg Engineering, Heidelberg, Germany) SD-OCT optic nerve head volume scans. One eye was randomly selected and analyzed for each subject. Using custom-designed software, the neuroretinal rim minimum distance band (MDB) thickness was calculated from volume scans, and global and quadrant neuroretinal rim thickness values were determined. The MDB is a three-dimensional neuroretinal rim band comprised of the shortest distance between the internal limiting membrane (ILM) and the termination of the retinal pigment epithelium/Bruch's membrane (RPE/BM) complex. Multiple linear regression analysis was performed to determine the associations of age, race, and gender with neuroretinal rim MDB measurements. Results: The population was 57% female and 69% Caucasian with a mean age of 58.4±15.3 years. Mean MDB thickness in the normal population was 278.4±47.5μm. For this normal population, MDB thickness decreased by 0.84μm annually (P<0.001). African Americans had thinner MDBs compared to Caucasians (P=0.003). Males and females had similar MDB thickness values (P=0.349). Conclusions: Neuroretinal rim MDB thickness measurements decreased significantly with age. African Americans had thinner MDB neuroretinal rims than Caucasians.
KW - neuroretinal rim
KW - optic nerve
KW - optical coherence tomography
UR - http://www.scopus.com/inward/record.url?scp=85073743505&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073743505&partnerID=8YFLogxK
U2 - 10.1097/IJG.0000000000001381
DO - 10.1097/IJG.0000000000001381
M3 - Article
C2 - 31599775
AN - SCOPUS:85073743505
JO - Journal of Glaucoma
JF - Journal of Glaucoma
SN - 1057-0829
ER -