Analysis of p53 and c-erbB-2 expression in ovarian endometrioid carcinomas arising in endometriosis

Federico Prefumo; Pier Luigi Venturini; Ezio Fulcheri

doi:10.1097/00004347-200301000-00016

Analysis of p53 and c-erbB-2 expression in ovarian endometrioid carcinomas arising in endometriosis

Federico Prefumo, Pier Luigi Venturini, Ezio Fulcheri

Research output: Contribution to journal › Article › peer-review

Abstract

We assessed the immunohistochemical expression of p53 and c-erbB-2 oncoproteins in 13 ovarian endometrioid adenocarcinomas arising from endometriosis (group 1) and compared the findings with 15 otherwise similar cases without associated endometriosis (group 2). Tumors in group 1 showed a higher expression of both p53 and c-erbB-2 (p=0.015 and p=0.048, respectively). The expression of the two proteins was also significantly associated in group 1 (p=0.013) but not in group 2 (p = 0.63) tumors. The different pattern of expression of p53 and c-erbB-2 in the two groups suggests that different molecular pathways may be involved in their pathogenesis.

Original language	English
Pages (from-to)	83-88
Number of pages	6
Journal	International Journal of Gynecological Pathology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1097/00004347-200301000-00016
Publication status	Published - Jan 2003

Keywords

c-erbB-2
Endometriosis
Ovarian endometrioid carcinoma
P53

ASJC Scopus subject areas

Pathology and Forensic Medicine
Obstetrics and Gynaecology

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10.1097/00004347-200301000-00016

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title = "Analysis of p53 and c-erbB-2 expression in ovarian endometrioid carcinomas arising in endometriosis",

abstract = "We assessed the immunohistochemical expression of p53 and c-erbB-2 oncoproteins in 13 ovarian endometrioid adenocarcinomas arising from endometriosis (group 1) and compared the findings with 15 otherwise similar cases without associated endometriosis (group 2). Tumors in group 1 showed a higher expression of both p53 and c-erbB-2 (p=0.015 and p=0.048, respectively). The expression of the two proteins was also significantly associated in group 1 (p=0.013) but not in group 2 (p = 0.63) tumors. The different pattern of expression of p53 and c-erbB-2 in the two groups suggests that different molecular pathways may be involved in their pathogenesis.",

keywords = "c-erbB-2, Endometriosis, Ovarian endometrioid carcinoma, P53",

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T1 - Analysis of p53 and c-erbB-2 expression in ovarian endometrioid carcinomas arising in endometriosis

AU - Prefumo, Federico

AU - Venturini, Pier Luigi

AU - Fulcheri, Ezio

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N2 - We assessed the immunohistochemical expression of p53 and c-erbB-2 oncoproteins in 13 ovarian endometrioid adenocarcinomas arising from endometriosis (group 1) and compared the findings with 15 otherwise similar cases without associated endometriosis (group 2). Tumors in group 1 showed a higher expression of both p53 and c-erbB-2 (p=0.015 and p=0.048, respectively). The expression of the two proteins was also significantly associated in group 1 (p=0.013) but not in group 2 (p = 0.63) tumors. The different pattern of expression of p53 and c-erbB-2 in the two groups suggests that different molecular pathways may be involved in their pathogenesis.

AB - We assessed the immunohistochemical expression of p53 and c-erbB-2 oncoproteins in 13 ovarian endometrioid adenocarcinomas arising from endometriosis (group 1) and compared the findings with 15 otherwise similar cases without associated endometriosis (group 2). Tumors in group 1 showed a higher expression of both p53 and c-erbB-2 (p=0.015 and p=0.048, respectively). The expression of the two proteins was also significantly associated in group 1 (p=0.013) but not in group 2 (p = 0.63) tumors. The different pattern of expression of p53 and c-erbB-2 in the two groups suggests that different molecular pathways may be involved in their pathogenesis.

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Analysis of p53 and c-erbB-2 expression in ovarian endometrioid carcinomas arising in endometriosis

Abstract

Keywords

ASJC Scopus subject areas

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