Abstract
We assessed the immunohistochemical expression of p53 and c-erbB-2 oncoproteins in 13 ovarian endometrioid adenocarcinomas arising from endometriosis (group 1) and compared the findings with 15 otherwise similar cases without associated endometriosis (group 2). Tumors in group 1 showed a higher expression of both p53 and c-erbB-2 (p=0.015 and p=0.048, respectively). The expression of the two proteins was also significantly associated in group 1 (p=0.013) but not in group 2 (p = 0.63) tumors. The different pattern of expression of p53 and c-erbB-2 in the two groups suggests that different molecular pathways may be involved in their pathogenesis.
Original language | English |
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Pages (from-to) | 83-88 |
Number of pages | 6 |
Journal | International Journal of Gynecological Pathology |
Volume | 22 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2003 |
Keywords
- c-erbB-2
- Endometriosis
- Ovarian endometrioid carcinoma
- P53
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Obstetrics and Gynaecology