Analysis of p53 and c-erbB-2 expression in ovarian endometrioid carcinomas arising in endometriosis

Federico Prefumo, Pier Luigi Venturini, Ezio Fulcheri

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed the immunohistochemical expression of p53 and c-erbB-2 oncoproteins in 13 ovarian endometrioid adenocarcinomas arising from endometriosis (group 1) and compared the findings with 15 otherwise similar cases without associated endometriosis (group 2). Tumors in group 1 showed a higher expression of both p53 and c-erbB-2 (p=0.015 and p=0.048, respectively). The expression of the two proteins was also significantly associated in group 1 (p=0.013) but not in group 2 (p = 0.63) tumors. The different pattern of expression of p53 and c-erbB-2 in the two groups suggests that different molecular pathways may be involved in their pathogenesis.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalInternational Journal of Gynecological Pathology
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 2003

Keywords

  • c-erbB-2
  • Endometriosis
  • Ovarian endometrioid carcinoma
  • P53

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology

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