Analysis of polyunsaturated fatty acids in newborn sera

A screening tool for atopic disease?

E. Galli, M. Picardo, L. Chini, S. Passi, V. Moschese, O. Terminali, F. Paone, G. Fraioli, P. Rossi

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

It has been demonstrated that patients with atopic disease have anomalies of fatty acid composition, as a result of altered metabolism or abnormal incorporation of fatty acids into the tissues. In the present study, in 57 newborns 'at risk' for atopic disease, the polyunsaturated fatty acid (PUFA) levels were found to be lower in cord blood in infants who subsequently developed atopic disease than in non-atopics. In all babies, levels of arachidonic acid and dihomo-gamma-linolenic acid in sera at 1 and 3 months of age were lower than those in cord blood. These changes were more marked in children who subsequently developed atopic disease, and in those who, independently of signs and/or symptoms of atopic disease, were formula-fed. A comparison between IgE and PUFA levels revealed no significant differences at any tested time interval. In conclusion, our data suggest that in children 'at risk' for atopy, PUFA levels may be predictive of atopic disease.

Original languageEnglish
Pages (from-to)752-756
Number of pages5
JournalBritish Journal of Dermatology
Volume130
Issue number6
DOIs
Publication statusPublished - 1994

Fingerprint

Unsaturated Fatty Acids
Newborn Infant
Serum
Fetal Blood
Fatty Acids
8,11,14-Eicosatrienoic Acid
Arachidonic Acid
Immunoglobulin E
Signs and Symptoms

ASJC Scopus subject areas

  • Dermatology

Cite this

Analysis of polyunsaturated fatty acids in newborn sera : A screening tool for atopic disease? / Galli, E.; Picardo, M.; Chini, L.; Passi, S.; Moschese, V.; Terminali, O.; Paone, F.; Fraioli, G.; Rossi, P.

In: British Journal of Dermatology, Vol. 130, No. 6, 1994, p. 752-756.

Research output: Contribution to journalArticle

Galli, E. ; Picardo, M. ; Chini, L. ; Passi, S. ; Moschese, V. ; Terminali, O. ; Paone, F. ; Fraioli, G. ; Rossi, P. / Analysis of polyunsaturated fatty acids in newborn sera : A screening tool for atopic disease?. In: British Journal of Dermatology. 1994 ; Vol. 130, No. 6. pp. 752-756.
@article{913e842b570b4f9d9079721887d943ae,
title = "Analysis of polyunsaturated fatty acids in newborn sera: A screening tool for atopic disease?",
abstract = "It has been demonstrated that patients with atopic disease have anomalies of fatty acid composition, as a result of altered metabolism or abnormal incorporation of fatty acids into the tissues. In the present study, in 57 newborns 'at risk' for atopic disease, the polyunsaturated fatty acid (PUFA) levels were found to be lower in cord blood in infants who subsequently developed atopic disease than in non-atopics. In all babies, levels of arachidonic acid and dihomo-gamma-linolenic acid in sera at 1 and 3 months of age were lower than those in cord blood. These changes were more marked in children who subsequently developed atopic disease, and in those who, independently of signs and/or symptoms of atopic disease, were formula-fed. A comparison between IgE and PUFA levels revealed no significant differences at any tested time interval. In conclusion, our data suggest that in children 'at risk' for atopy, PUFA levels may be predictive of atopic disease.",
author = "E. Galli and M. Picardo and L. Chini and S. Passi and V. Moschese and O. Terminali and F. Paone and G. Fraioli and P. Rossi",
year = "1994",
doi = "10.1111/j.1365-2133.1994.tb03413.x",
language = "English",
volume = "130",
pages = "752--756",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Blackwell Publishing Ltd",
number = "6",

}

TY - JOUR

T1 - Analysis of polyunsaturated fatty acids in newborn sera

T2 - A screening tool for atopic disease?

AU - Galli, E.

AU - Picardo, M.

AU - Chini, L.

AU - Passi, S.

AU - Moschese, V.

AU - Terminali, O.

AU - Paone, F.

AU - Fraioli, G.

AU - Rossi, P.

PY - 1994

Y1 - 1994

N2 - It has been demonstrated that patients with atopic disease have anomalies of fatty acid composition, as a result of altered metabolism or abnormal incorporation of fatty acids into the tissues. In the present study, in 57 newborns 'at risk' for atopic disease, the polyunsaturated fatty acid (PUFA) levels were found to be lower in cord blood in infants who subsequently developed atopic disease than in non-atopics. In all babies, levels of arachidonic acid and dihomo-gamma-linolenic acid in sera at 1 and 3 months of age were lower than those in cord blood. These changes were more marked in children who subsequently developed atopic disease, and in those who, independently of signs and/or symptoms of atopic disease, were formula-fed. A comparison between IgE and PUFA levels revealed no significant differences at any tested time interval. In conclusion, our data suggest that in children 'at risk' for atopy, PUFA levels may be predictive of atopic disease.

AB - It has been demonstrated that patients with atopic disease have anomalies of fatty acid composition, as a result of altered metabolism or abnormal incorporation of fatty acids into the tissues. In the present study, in 57 newborns 'at risk' for atopic disease, the polyunsaturated fatty acid (PUFA) levels were found to be lower in cord blood in infants who subsequently developed atopic disease than in non-atopics. In all babies, levels of arachidonic acid and dihomo-gamma-linolenic acid in sera at 1 and 3 months of age were lower than those in cord blood. These changes were more marked in children who subsequently developed atopic disease, and in those who, independently of signs and/or symptoms of atopic disease, were formula-fed. A comparison between IgE and PUFA levels revealed no significant differences at any tested time interval. In conclusion, our data suggest that in children 'at risk' for atopy, PUFA levels may be predictive of atopic disease.

UR - http://www.scopus.com/inward/record.url?scp=0028304972&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028304972&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2133.1994.tb03413.x

DO - 10.1111/j.1365-2133.1994.tb03413.x

M3 - Article

VL - 130

SP - 752

EP - 756

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 6

ER -