Analysis of stroke occurring in the SYNTAX trial comparing coronary artery bypass surgery and percutaneous coronary intervention in the treatment of complex coronary artery disease

Michael J. MacK, Stuart J. Head, David R. Holmes, Elisabeth Ståhle, Ted E. Feldman, Antonio Colombo, Marie Claude Morice, Felix Unger, Andrejs Erglis, Robert Stoler, Keith D. Dawkins, Patrick W. Serruys, Friedrich W. Mohr, A. Pieter Kappetein

Research output: Contribution to journalArticle

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Abstract

Objectives: This study sought to analyze stroke rates in the SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) trial's randomized and registry cohorts of patients being treated with coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) for treatment of complex coronary artery disease. Background: The SYNTAX trial compared PCI to CABG in patients with de novo 3-vessel and/or left main coronary disease. Methods: The SYNTAX randomized trial was conducted at 85 U.S. and European sites (n = 1,800). All strokes (up to 4 years) were independently adjudicated by a clinical events committee that included a neurologist. An additional 1,077 (of which 644 were followed for 5 years) and 198 patients were included in the CABG and PCI registries, respectively. Results: In the randomized cohort, 31 CABG and 19 PCI patients experienced 33 and 20 strokes post-randomization at 4-year follow-up, respectively (p = 0.062). Three strokes occurred pre-procedurally but following randomization in CABG-treated patients. After CABG, a large proportion of strokes occurred acutely (0 to 30 days: 9 of 33), whereas in the PCI arm, most strokes occurred >30 days after the procedure (18 of 20). Stroke resulted in death in 3 patients in both the PCI and CABG groups. Of the patients who developed stroke, 68% (21 of 31) in the CABG group had residual deficits at discharge; in the PCI group, 47% (9 of 19) had residual deficits. In a multivariate analysis, treatment with CABG was not significantly associated with increased stroke rates (odds ratio: 1.67, 95% confidence interval: 0.93 to 3.01, p = 0.089). The incidence and outcomes of stroke were similar in the randomized trial and registries. Conclusions: There is a higher risk of periprocedural stroke in patients undergoing CABG versus PCI; however, the risk converges over the first 4 years of follow-up.

Original languageEnglish
Pages (from-to)344-354
Number of pages11
JournalJACC: Cardiovascular Interventions
Volume6
Issue number4
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Percutaneous Coronary Intervention
Coronary Artery Bypass
Coronary Artery Disease
Stroke
Therapeutics
Registries
Random Allocation
Taxus
Thoracic Surgery
Coronary Disease
Multivariate Analysis
Odds Ratio
Confidence Intervals

Keywords

  • coronary artery bypass graft
  • drug-eluting stent(s)
  • percutaneous coronary intervention
  • stroke
  • SYNTAX
  • Taxus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Analysis of stroke occurring in the SYNTAX trial comparing coronary artery bypass surgery and percutaneous coronary intervention in the treatment of complex coronary artery disease. / MacK, Michael J.; Head, Stuart J.; Holmes, David R.; Ståhle, Elisabeth; Feldman, Ted E.; Colombo, Antonio; Morice, Marie Claude; Unger, Felix; Erglis, Andrejs; Stoler, Robert; Dawkins, Keith D.; Serruys, Patrick W.; Mohr, Friedrich W.; Kappetein, A. Pieter.

In: JACC: Cardiovascular Interventions, Vol. 6, No. 4, 04.2013, p. 344-354.

Research output: Contribution to journalArticle

MacK, MJ, Head, SJ, Holmes, DR, Ståhle, E, Feldman, TE, Colombo, A, Morice, MC, Unger, F, Erglis, A, Stoler, R, Dawkins, KD, Serruys, PW, Mohr, FW & Kappetein, AP 2013, 'Analysis of stroke occurring in the SYNTAX trial comparing coronary artery bypass surgery and percutaneous coronary intervention in the treatment of complex coronary artery disease', JACC: Cardiovascular Interventions, vol. 6, no. 4, pp. 344-354. https://doi.org/10.1016/j.jcin.2012.11.010
MacK, Michael J. ; Head, Stuart J. ; Holmes, David R. ; Ståhle, Elisabeth ; Feldman, Ted E. ; Colombo, Antonio ; Morice, Marie Claude ; Unger, Felix ; Erglis, Andrejs ; Stoler, Robert ; Dawkins, Keith D. ; Serruys, Patrick W. ; Mohr, Friedrich W. ; Kappetein, A. Pieter. / Analysis of stroke occurring in the SYNTAX trial comparing coronary artery bypass surgery and percutaneous coronary intervention in the treatment of complex coronary artery disease. In: JACC: Cardiovascular Interventions. 2013 ; Vol. 6, No. 4. pp. 344-354.
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T1 - Analysis of stroke occurring in the SYNTAX trial comparing coronary artery bypass surgery and percutaneous coronary intervention in the treatment of complex coronary artery disease

AU - MacK, Michael J.

AU - Head, Stuart J.

AU - Holmes, David R.

AU - Ståhle, Elisabeth

AU - Feldman, Ted E.

AU - Colombo, Antonio

AU - Morice, Marie Claude

AU - Unger, Felix

AU - Erglis, Andrejs

AU - Stoler, Robert

AU - Dawkins, Keith D.

AU - Serruys, Patrick W.

AU - Mohr, Friedrich W.

AU - Kappetein, A. Pieter

PY - 2013/4

Y1 - 2013/4

N2 - Objectives: This study sought to analyze stroke rates in the SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) trial's randomized and registry cohorts of patients being treated with coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) for treatment of complex coronary artery disease. Background: The SYNTAX trial compared PCI to CABG in patients with de novo 3-vessel and/or left main coronary disease. Methods: The SYNTAX randomized trial was conducted at 85 U.S. and European sites (n = 1,800). All strokes (up to 4 years) were independently adjudicated by a clinical events committee that included a neurologist. An additional 1,077 (of which 644 were followed for 5 years) and 198 patients were included in the CABG and PCI registries, respectively. Results: In the randomized cohort, 31 CABG and 19 PCI patients experienced 33 and 20 strokes post-randomization at 4-year follow-up, respectively (p = 0.062). Three strokes occurred pre-procedurally but following randomization in CABG-treated patients. After CABG, a large proportion of strokes occurred acutely (0 to 30 days: 9 of 33), whereas in the PCI arm, most strokes occurred >30 days after the procedure (18 of 20). Stroke resulted in death in 3 patients in both the PCI and CABG groups. Of the patients who developed stroke, 68% (21 of 31) in the CABG group had residual deficits at discharge; in the PCI group, 47% (9 of 19) had residual deficits. In a multivariate analysis, treatment with CABG was not significantly associated with increased stroke rates (odds ratio: 1.67, 95% confidence interval: 0.93 to 3.01, p = 0.089). The incidence and outcomes of stroke were similar in the randomized trial and registries. Conclusions: There is a higher risk of periprocedural stroke in patients undergoing CABG versus PCI; however, the risk converges over the first 4 years of follow-up.

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KW - drug-eluting stent(s)

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KW - stroke

KW - SYNTAX

KW - Taxus

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