Analysis of T-cell receptor Beta Chain (T(β)) gene rearrangements demonstrates the monoclonal nature of T-cell chronic lymphoproliferative disorders

R. Foa, P. G. Pelicci, N. Migone, F. Lauria, G. Pizzolo, F. Flug, D. M. Knowles, R. Dalla-Favera

Research output: Contribution to journalArticle

Abstract

We investigated the rearrangement patterns of the gene coding for the beta chain of the T cell receptor (T(β)) in 11 patients with T-cell derived chronic lymphoproliferative disorders, including T-cell prolymphocytic leukemia (T-PLL) and T-cell chronic lymphocytic leukemia (T-CLL). We found that all five cases of T-PLL, and five of six cases of T-CLL, displayed T(β)-gene rearrangements, clearly establishing their monoclonal nature. Clonality could not be determined in one case of T-CLL where the T(β) gene was found unrearranged. Our results demonstrate that the majority of cases of both clinically aggressive T-PLL and clinically indolent T-CLL are monoclonal. These results suggest that the analysis of T(β) gene rearrangements represents a valid tool for the differential diagnosis and clinical monitoring of T-cell derived chronic lymphoproliferative diseases.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalBlood
Volume67
Issue number1
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Hematology

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    Foa, R., Pelicci, P. G., Migone, N., Lauria, F., Pizzolo, G., Flug, F., Knowles, D. M., & Dalla-Favera, R. (1986). Analysis of T-cell receptor Beta Chain (T(β)) gene rearrangements demonstrates the monoclonal nature of T-cell chronic lymphoproliferative disorders. Blood, 67(1), 247-250.