Analysis of TCR usage in human tumors: a new tool for assessing tumor-specific immune responses

Marialuisa Sensi, Giorgio Parmiani

Research output: Contribution to journalArticlepeer-review

Abstract

Tumor-infiltrating lymphocytes (TILs), through displaying a T-cell receptor (TCR) repertoire as heterogeneous as that of normal peripheral blood T cells, show overexpression of TCR variable-gene segments that include clonally expanded TCR sequences. Here, Marialuisa Sensi and Giorgio Parmiani analyze the available information on TCR usage by T cells present in the infiltrate of histologically different tumors and suggest that the analysis of TCR sequences represent a powerful new tool to assess thein vivo immune response to growing tumors. Ultimately, this strategy may lead to the identification and manipulation of T-cell populations endowed with antitumor reactivity.

Original languageEnglish
Pages (from-to)588-595
Number of pages8
JournalImmunology Today
Volume16
Issue number12
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Immunology

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