Abstract
Tumor-infiltrating lymphocytes (TILs), through displaying a T-cell receptor (TCR) repertoire as heterogeneous as that of normal peripheral blood T cells, show overexpression of TCR variable-gene segments that include clonally expanded TCR sequences. Here, Marialuisa Sensi and Giorgio Parmiani analyze the available information on TCR usage by T cells present in the infiltrate of histologically different tumors and suggest that the analysis of TCR sequences represent a powerful new tool to assess thein vivo immune response to growing tumors. Ultimately, this strategy may lead to the identification and manipulation of T-cell populations endowed with antitumor reactivity.
Original language | English |
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Pages (from-to) | 588-595 |
Number of pages | 8 |
Journal | Immunology Today |
Volume | 16 |
Issue number | 12 |
DOIs | |
Publication status | Published - 1995 |
ASJC Scopus subject areas
- Immunology