Abstract
The γ-chain structure of a homozygote for HPFH Negro type, previously described by Acquaye and co-workers, and of 3 heterozygotes of the same family has been evaluated.Gγ andAγ chains were present in a ratio of fetal type (7/3) in the homozygote and in ratios of 2/3 and 1/1 in the heterozygotes, in agreement with data of the literature.Tγ chains were absent in all the cases. Our results, compared with those previously reported for Negro and Greek HPFH, suggest that theTγ gene is never linked with the HPFH determinant.
| Original language | English |
|---|---|
| Pages (from-to) | 146-150 |
| Number of pages | 5 |
| Journal | Acta Haematologica |
| Volume | 63 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1980 |
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Keywords
- Hb F
- HPFH Negro type
- γ-Chain composition
ASJC Scopus subject areas
- Hematology
Cite this
Analysis of the γ chains in a homozygote for HPFH negro type and in three related heterozygotes. / Guerrasio, A.; Acquaye, C. T A; Oldham, J. H.; Sartoris, M. L.; Camaschella, C.; Saglio, G.; Mazza, U.
In: Acta Haematologica, Vol. 63, No. 3, 1980, p. 146-150.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of the γ chains in a homozygote for HPFH negro type and in three related heterozygotes
AU - Guerrasio, A.
AU - Acquaye, C. T A
AU - Oldham, J. H.
AU - Sartoris, M. L.
AU - Camaschella, C.
AU - Saglio, G.
AU - Mazza, U.
PY - 1980
Y1 - 1980
N2 - The γ-chain structure of a homozygote for HPFH Negro type, previously described by Acquaye and co-workers, and of 3 heterozygotes of the same family has been evaluated.Gγ andAγ chains were present in a ratio of fetal type (7/3) in the homozygote and in ratios of 2/3 and 1/1 in the heterozygotes, in agreement with data of the literature.Tγ chains were absent in all the cases. Our results, compared with those previously reported for Negro and Greek HPFH, suggest that theTγ gene is never linked with the HPFH determinant.
AB - The γ-chain structure of a homozygote for HPFH Negro type, previously described by Acquaye and co-workers, and of 3 heterozygotes of the same family has been evaluated.Gγ andAγ chains were present in a ratio of fetal type (7/3) in the homozygote and in ratios of 2/3 and 1/1 in the heterozygotes, in agreement with data of the literature.Tγ chains were absent in all the cases. Our results, compared with those previously reported for Negro and Greek HPFH, suggest that theTγ gene is never linked with the HPFH determinant.
KW - Hb F
KW - HPFH Negro type
KW - γ-Chain composition
UR - http://www.scopus.com/inward/record.url?scp=0018841652&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018841652&partnerID=8YFLogxK
U2 - 10.1159/000207386
DO - 10.1159/000207386
M3 - Article
C2 - 6155042
AN - SCOPUS:0018841652
VL - 63
SP - 146
EP - 150
JO - Acta Haematologica
JF - Acta Haematologica
SN - 0001-5792
IS - 3
ER -