Analysis of the γ chains in a homozygote for HPFH negro type and in three related heterozygotes

A. Guerrasio, C. T A Acquaye, J. H. Oldham, M. L. Sartoris, C. Camaschella, G. Saglio, U. Mazza

Research output: Contribution to journalArticlepeer-review

Abstract

The γ-chain structure of a homozygote for HPFH Negro type, previously described by Acquaye and co-workers, and of 3 heterozygotes of the same family has been evaluated.Gγ andAγ chains were present in a ratio of fetal type (7/3) in the homozygote and in ratios of 2/3 and 1/1 in the heterozygotes, in agreement with data of the literature.Tγ chains were absent in all the cases. Our results, compared with those previously reported for Negro and Greek HPFH, suggest that theTγ gene is never linked with the HPFH determinant.

Original languageEnglish
Pages (from-to)146-150
Number of pages5
JournalActa Haematologica
Volume63
Issue number3
DOIs
Publication statusPublished - 1980

Keywords

  • Hb F
  • HPFH Negro type
  • γ-Chain composition

ASJC Scopus subject areas

  • Hematology

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