Analysis of the γ chains in a homozygote for HPFH negro type and in three related heterozygotes

The γ-chain structure of a homozygote for HPFH Negro type, previously described by Acquaye and co-workers, and of 3 heterozygotes of the same family has been evaluated.^Gγ and^Aγ chains were present in a ratio of fetal type (7/3) in the homozygote and in ratios of 2/3 and 1/1 in the heterozygotes, in agreement with data of the literature.^Tγ chains were absent in all the cases. Our results, compared with those previously reported for Negro and Greek HPFH, suggest that the^Tγ gene is never linked with the HPFH determinant.