Analysis of the γ chains in a homozygote for HPFH negro type and in three related heterozygotes

A. Guerrasio; C. T A Acquaye; J. H. Oldham; M. L. Sartoris; C. Camaschella; G. Saglio; U. Mazza

doi:10.1159/000207386

Analysis of the γ chains in a homozygote for HPFH negro type and in three related heterozygotes

A. Guerrasio, C. T A Acquaye, J. H. Oldham, M. L. Sartoris, C. Camaschella, G. Saglio, U. Mazza

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The γ-chain structure of a homozygote for HPFH Negro type, previously described by Acquaye and co-workers, and of 3 heterozygotes of the same family has been evaluated.^Gγ and^Aγ chains were present in a ratio of fetal type (7/3) in the homozygote and in ratios of 2/3 and 1/1 in the heterozygotes, in agreement with data of the literature.^Tγ chains were absent in all the cases. Our results, compared with those previously reported for Negro and Greek HPFH, suggest that the^Tγ gene is never linked with the HPFH determinant.

Original language	English
Pages (from-to)	146-150
Number of pages	5
Journal	Acta Haematologica
Volume	63
Issue number	3
DOIs	https://doi.org/10.1159/000207386
Publication status	Published - 1980

Keywords

Hb F
HPFH Negro type
γ-Chain composition

ASJC Scopus subject areas

Hematology

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10.1159/000207386

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abstract = "The γ-chain structure of a homozygote for HPFH Negro type, previously described by Acquaye and co-workers, and of 3 heterozygotes of the same family has been evaluated.Gγ andAγ chains were present in a ratio of fetal type (7/3) in the homozygote and in ratios of 2/3 and 1/1 in the heterozygotes, in agreement with data of the literature.Tγ chains were absent in all the cases. Our results, compared with those previously reported for Negro and Greek HPFH, suggest that theTγ gene is never linked with the HPFH determinant.",

keywords = "Hb F, HPFH Negro type, γ-Chain composition",

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T1 - Analysis of the γ chains in a homozygote for HPFH negro type and in three related heterozygotes

AU - Guerrasio, A.

AU - Acquaye, C. T A

AU - Oldham, J. H.

AU - Sartoris, M. L.

AU - Camaschella, C.

AU - Saglio, G.

AU - Mazza, U.

PY - 1980

Y1 - 1980

N2 - The γ-chain structure of a homozygote for HPFH Negro type, previously described by Acquaye and co-workers, and of 3 heterozygotes of the same family has been evaluated.Gγ andAγ chains were present in a ratio of fetal type (7/3) in the homozygote and in ratios of 2/3 and 1/1 in the heterozygotes, in agreement with data of the literature.Tγ chains were absent in all the cases. Our results, compared with those previously reported for Negro and Greek HPFH, suggest that theTγ gene is never linked with the HPFH determinant.

AB - The γ-chain structure of a homozygote for HPFH Negro type, previously described by Acquaye and co-workers, and of 3 heterozygotes of the same family has been evaluated.Gγ andAγ chains were present in a ratio of fetal type (7/3) in the homozygote and in ratios of 2/3 and 1/1 in the heterozygotes, in agreement with data of the literature.Tγ chains were absent in all the cases. Our results, compared with those previously reported for Negro and Greek HPFH, suggest that theTγ gene is never linked with the HPFH determinant.

KW - Hb F

KW - HPFH Negro type

KW - γ-Chain composition

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Analysis of the γ chains in a homozygote for HPFH negro type and in three related heterozygotes

Abstract

Keywords

ASJC Scopus subject areas

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