Analysis of the BCL-6 gene configuration in diffuse B-cell non-Hodgkin's lymphomas and Hodgkin's disease

E. Pescarmona, F. Lo Coco, A. Pacchiarotti, M. C. Rapanotti, G. Cimino, B. Di Paolo, C. D. Baroni

Research output: Contribution to journalArticle

Abstract

BCL-6 is a novel proto-oncogene that codes for a zinc-finger protein sharing homologies with many transcription Factors. It has recently been shown that BCL-6 is involved in chromosome band 3q27 aberrations in non-Hodgkin's lymphomas (NHLs) and BCL-6 rearrangements have been detected in 34-45 per cent of diffuse large cell lymphomas with B immunophenotype. We have studied the BCL-6 gene configuration by Southern blot analysis in 60 cases of B-cell NHL and in 17 cases of Hodgkin's disease (HD). BCL-6 was rearranged in 15/46 (32.6 per cent) diffuse B-large cell lymphomas, mainly with centroblastic morphology, and in 2/11 (18.2 per cent) follicular (centroblastic-centrocytic) lymphomas. Conversely, all cases of HD, including four cases of lymphocyte predominant, nodular type (nodular paragranuloma), had a germline configuration. These findings confirm that BCL-6 is rearranged in a significant percentage of diffuse B-large cell lymphomas, suggesting that this proto-oncogene might have a pathogenetic role in this subset of NHLs, but our preliminary analysis suggests that BCL-6 lesions are not involved in the pathogenesis of HD. However, further investigations using more sensitive techniques are required to confirm these findings.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalJournal of Pathology
Volume177
Issue number1
DOIs
Publication statusPublished - 1995

Keywords

  • BCL-6
  • Hodgkin's disease
  • Non-Hodgkin's lymphomas
  • Oncogenes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Pescarmona, E., Lo Coco, F., Pacchiarotti, A., Rapanotti, M. C., Cimino, G., Di Paolo, B., & Baroni, C. D. (1995). Analysis of the BCL-6 gene configuration in diffuse B-cell non-Hodgkin's lymphomas and Hodgkin's disease. Journal of Pathology, 177(1), 21-25. https://doi.org/10.1002/path.1711770105