TY - JOUR
T1 - Analysis of the chronic lymphocytic leukemia coding genome
T2 - Role of NOTCH1 mutational activation
AU - Fabbri, Giulia
AU - Rasi, Silvia
AU - Rossi, Davide
AU - Trifonov, Vladimir
AU - Khiabanian, Hossein
AU - Ma, Jing
AU - Grunn, Adina
AU - Fangazio, Marco
AU - Capello, Daniela
AU - Monti, Sara
AU - Cresta, Stefania
AU - Gargiulo, Ernesto
AU - Forconi, Francesco
AU - Guarini, Anna
AU - Arcaini, Luca
AU - Paulli, Marco
AU - Laurenti, Luca
AU - Larocca, Luigi M.
AU - Marasca, Roberto
AU - Gattei, Valter
AU - Oscier, David
AU - Bertoni, Francesco
AU - Mullighan, Charles G.
AU - Foà, Robin
AU - Pasqualucci, Laura
AU - Rabadan, Raul
AU - Dalla-Favera, Riccardo
AU - Gaidano, Gianluca
PY - 2011/7/4
Y1 - 2011/7/4
N2 - The pathogenesis of chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is still largely unknown. The full spectrum of genetic lesions that are present in the CLL genome, and therefore the number and identity of dysregulated cellular pathways, have not been identified. By combining next-generation sequencing and copy number analysis, we show here that the typical CLL coding genome contains
AB - The pathogenesis of chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is still largely unknown. The full spectrum of genetic lesions that are present in the CLL genome, and therefore the number and identity of dysregulated cellular pathways, have not been identified. By combining next-generation sequencing and copy number analysis, we show here that the typical CLL coding genome contains
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U2 - 10.1084/jem.20110921
DO - 10.1084/jem.20110921
M3 - Article
C2 - 21670202
AN - SCOPUS:79960353160
VL - 208
SP - 1389
EP - 1401
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
SN - 0022-1007
IS - 7
ER -