Analysis of the chronic lymphocytic leukemia coding genome: Role of NOTCH1 mutational activation

Giulia Fabbri, Silvia Rasi, Davide Rossi, Vladimir Trifonov, Hossein Khiabanian, Jing Ma, Adina Grunn, Marco Fangazio, Daniela Capello, Sara Monti, Stefania Cresta, Ernesto Gargiulo, Francesco Forconi, Anna Guarini, Luca Arcaini, Marco Paulli, Luca Laurenti, Luigi M. Larocca, Roberto Marasca, Valter GatteiDavid Oscier, Francesco Bertoni, Charles G. Mullighan, Robin Foà, Laura Pasqualucci, Raul Rabadan, Riccardo Dalla-Favera, Gianluca Gaidano

Research output: Contribution to journalArticlepeer-review

Abstract

The pathogenesis of chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is still largely unknown. The full spectrum of genetic lesions that are present in the CLL genome, and therefore the number and identity of dysregulated cellular pathways, have not been identified. By combining next-generation sequencing and copy number analysis, we show here that the typical CLL coding genome contains

Original languageEnglish
Pages (from-to)1389-1401
Number of pages13
JournalJournal of Experimental Medicine
Volume208
Issue number7
DOIs
Publication statusPublished - Jul 4 2011

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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