Abstract
In ten sino-aortic denervated, vagotomized and anaesthetized cats, renal efferent nerves were stimulated for 30 s with trains of constant current pulses at frequencies in the range 5-30 Hz. The arterial pressure, heart rate, urine flow rate (electronic drop counter) and renal blood flow (electromagnetic technique) were recorded. Subsequent computer processing gave the true means of renal artery pressure (MRAP) and renal blood flow (MRBF) and hence the renal vascular resistance (MRVR), over each cardiac cycle. Recovery of MRVR after the end of stimulation exhibited two distinct time constants. The fast component had a time constant of 2.03 ± 0.26 s and represented 60.2 ± 1.71% of the recovery. The time constant of the slower component was 14.1 ± 1.9 s and represented 36.0 ± 1.6% of the recovery. The relationship between MRVR and stimulus frequency was sigmoidal with maximum sensitivity at stimulus frequencies of 12.6 ± 0.76 Hz. Changes in urine flow rate, in contrast, followed a hyperbolic function with maximum response sensitivity occurring at very low stimulus frequencies. Changes in urine flow rate were 50% complete at stimulus frequencies of 5 Hz. Identification of two distinct components in the relaxation phase of renal vascular resistance leads to a reasonable hypothesis that 60% of total renal vascular resistance may lie proximal to the glomerulus, whereas 36% may be accounted for by the efferent arterioles.
| Original language | English |
|---|---|
| Pages (from-to) | 213-228 |
| Number of pages | 16 |
| Journal | Physiological Measurement |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1996 |
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Keywords
- Cat
- Renal efferent nerves
- Renal function
- Renal vascular resistance
- Urine flow rate
ASJC Scopus subject areas
- Biophysics
Cite this
Analysis of the dynamics of renal vascular resistance and urine flow rate in the cat following electrical stimulation of the renal nerves. / Celler, B. G.; Stella, A.; Golin, R.; Zanchetti, A.
In: Physiological Measurement, Vol. 17, No. 3, 1996, p. 213-228.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of the dynamics of renal vascular resistance and urine flow rate in the cat following electrical stimulation of the renal nerves
AU - Celler, B. G.
AU - Stella, A.
AU - Golin, R.
AU - Zanchetti, A.
PY - 1996
Y1 - 1996
N2 - In ten sino-aortic denervated, vagotomized and anaesthetized cats, renal efferent nerves were stimulated for 30 s with trains of constant current pulses at frequencies in the range 5-30 Hz. The arterial pressure, heart rate, urine flow rate (electronic drop counter) and renal blood flow (electromagnetic technique) were recorded. Subsequent computer processing gave the true means of renal artery pressure (MRAP) and renal blood flow (MRBF) and hence the renal vascular resistance (MRVR), over each cardiac cycle. Recovery of MRVR after the end of stimulation exhibited two distinct time constants. The fast component had a time constant of 2.03 ± 0.26 s and represented 60.2 ± 1.71% of the recovery. The time constant of the slower component was 14.1 ± 1.9 s and represented 36.0 ± 1.6% of the recovery. The relationship between MRVR and stimulus frequency was sigmoidal with maximum sensitivity at stimulus frequencies of 12.6 ± 0.76 Hz. Changes in urine flow rate, in contrast, followed a hyperbolic function with maximum response sensitivity occurring at very low stimulus frequencies. Changes in urine flow rate were 50% complete at stimulus frequencies of 5 Hz. Identification of two distinct components in the relaxation phase of renal vascular resistance leads to a reasonable hypothesis that 60% of total renal vascular resistance may lie proximal to the glomerulus, whereas 36% may be accounted for by the efferent arterioles.
AB - In ten sino-aortic denervated, vagotomized and anaesthetized cats, renal efferent nerves were stimulated for 30 s with trains of constant current pulses at frequencies in the range 5-30 Hz. The arterial pressure, heart rate, urine flow rate (electronic drop counter) and renal blood flow (electromagnetic technique) were recorded. Subsequent computer processing gave the true means of renal artery pressure (MRAP) and renal blood flow (MRBF) and hence the renal vascular resistance (MRVR), over each cardiac cycle. Recovery of MRVR after the end of stimulation exhibited two distinct time constants. The fast component had a time constant of 2.03 ± 0.26 s and represented 60.2 ± 1.71% of the recovery. The time constant of the slower component was 14.1 ± 1.9 s and represented 36.0 ± 1.6% of the recovery. The relationship between MRVR and stimulus frequency was sigmoidal with maximum sensitivity at stimulus frequencies of 12.6 ± 0.76 Hz. Changes in urine flow rate, in contrast, followed a hyperbolic function with maximum response sensitivity occurring at very low stimulus frequencies. Changes in urine flow rate were 50% complete at stimulus frequencies of 5 Hz. Identification of two distinct components in the relaxation phase of renal vascular resistance leads to a reasonable hypothesis that 60% of total renal vascular resistance may lie proximal to the glomerulus, whereas 36% may be accounted for by the efferent arterioles.
KW - Cat
KW - Renal efferent nerves
KW - Renal function
KW - Renal vascular resistance
KW - Urine flow rate
UR - http://www.scopus.com/inward/record.url?scp=0029811067&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029811067&partnerID=8YFLogxK
U2 - 10.1088/0967-3334/17/3/007
DO - 10.1088/0967-3334/17/3/007
M3 - Article
C2 - 8870061
AN - SCOPUS:0029811067
VL - 17
SP - 213
EP - 228
JO - Physiological Measurement
JF - Physiological Measurement
SN - 0967-3334
IS - 3
ER -