Analysis of the immunoglobulin heavy-chain gene rearrangement providing molecular evidence of second lymphoma in a patient in apparent relapse after autotransplantation

S. Campana, P. Corradini, M. Astolfi, M. Ladetto, F. Cinque, D. Novero, C. Tarella, A. Pileri

Research output: Contribution to journalArticle


Development of a second lymphoma after autotransplantation is an unusual event. Its real incidence, however, could be underestimated, since histologic and immunophenotyping techniques are often unable to distinguish it from a relapse. We report a lymphoma patient in apparent relapse after 42 months of molecular remission achieved by autotransplantation. Sequencing analysis of the immunoglobulin heavy-chain genes showed that the rearrangement of variable, diversity and joining segments had changed between diagnosis and relapse and suggested that a second lymphoma had developed.

Original languageEnglish
Pages (from-to)341-343
Number of pages3
JournalBone Marrow Transplantation
Issue number4
Publication statusPublished - Aug 2 1997



  • Autotransplantation
  • IgH genes
  • Minimal residual disease
  • Non-Hodgkin lymphoma
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this