Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: A multicenter survival study

Perry T C van Doormaal; Nicola Ticozzi; Cinzia Gellera; Antonia Ratti; Franco Taroni; Adriano Chiò; Andrea Calvo; Gabriele Mora; Gabriella Restagno; Bryan J. Traynor; Anna Birve; Robin Lemmens; Michael A. van Es; Christiaan G J Saris; Hylke M. Blauw; Paul W J van Vught; Ewout J N Groen; Lucia Corrado; Letizia Mazzini; Roberto Del Bo; Stefania Corti; Stefan Waibel; Thomas Meyer; Albert C. Ludolph; An Goris; Philip van Damme; Wim Robberecht; Aleksey Shatunov; Isabella Fogh; Peter M. Andersen; Sandra D'Alfonso; Orla Hardiman; Simon Cronin; Dan Rujescu; Ammar Al-Chalabi; John E. Landers; Vincenzo Silani; Leonard H. van den Berg; Jan H. Veldink

doi:10.1016/j.neurobiolaging.2014.04.014

Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: A multicenter survival study

Perry T C van Doormaal, Nicola Ticozzi, Cinzia Gellera, Antonia Ratti, Franco Taroni, Adriano Chiò, Andrea Calvo, Gabriele Mora, Gabriella Restagno, Bryan J. Traynor, Anna Birve, Robin Lemmens, Michael A. van Es, Christiaan G J Saris, Hylke M. Blauw, Paul W J van Vught, Ewout J N Groen, Lucia Corrado, Letizia Mazzini, Roberto Del BoStefania Corti, Stefan Waibel, Thomas Meyer, Albert C. Ludolph, An Goris, Philip van Damme, Wim Robberecht, Aleksey Shatunov, Isabella Fogh, Peter M. Andersen, Sandra D'Alfonso, Orla Hardiman, Simon Cronin, Dan Rujescu, Ammar Al-Chalabi, John E. Landers, Vincenzo Silani, Leonard H. van den Berg, Jan H. Veldink

Research output: Contribution to journal › Article › peer-review

Abstract

Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n= 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group.

Original language	English
Journal	Neurobiology of Aging
Volume	35
Issue number	10
DOIs	https://doi.org/10.1016/j.neurobiolaging.2014.04.014
Publication status	Published - 2014

Keywords

Amyotrophic lateral sclerosis
Genome-wide association study
KIFAP3
Kinesin-associated protein 3 gene

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)
Ageing
Developmental Biology
Geriatrics and Gerontology

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van Doormaal, P. T. C., Ticozzi, N., Gellera, C., Ratti, A., Taroni, F., Chiò, A., Calvo, A., Mora, G., Restagno, G., Traynor, B. J., Birve, A., Lemmens, R., van Es, M. A., Saris, C. G. J., Blauw, H. M., van Vught, P. W. J., Groen, E. J. N., Corrado, L., Mazzini, L., ... Veldink, J. H. (2014). Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: A multicenter survival study. Neurobiology of Aging, 35(10). https://doi.org/10.1016/j.neurobiolaging.2014.04.014

Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis : A multicenter survival study. / van Doormaal, Perry T C; Ticozzi, Nicola ; Gellera, Cinzia ; Ratti, Antonia ; Taroni, Franco; Chiò, Adriano; Calvo, Andrea; Mora, Gabriele; Restagno, Gabriella; Traynor, Bryan J.; Birve, Anna; Lemmens, Robin; van Es, Michael A.; Saris, Christiaan G J; Blauw, Hylke M.; van Vught, Paul W J; Groen, Ewout J N; Corrado, Lucia; Mazzini, Letizia; Del Bo, Roberto; Corti, Stefania; Waibel, Stefan; Meyer, Thomas; Ludolph, Albert C.; Goris, An; van Damme, Philip; Robberecht, Wim; Shatunov, Aleksey; Fogh, Isabella; Andersen, Peter M.; D'Alfonso, Sandra; Hardiman, Orla; Cronin, Simon; Rujescu, Dan; Al-Chalabi, Ammar; Landers, John E.; Silani, Vincenzo; van den Berg, Leonard H.; Veldink, Jan H.

In: Neurobiology of Aging, Vol. 35, No. 10, 2014.

Research output: Contribution to journal › Article › peer-review

van Doormaal, PTC, Ticozzi, N , Gellera, C , Ratti, A , Taroni, F, Chiò, A, Calvo, A, Mora, G, Restagno, G, Traynor, BJ, Birve, A, Lemmens, R, van Es, MA, Saris, CGJ, Blauw, HM, van Vught, PWJ, Groen, EJN, Corrado, L, Mazzini, L, Del Bo, R, Corti, S, Waibel, S, Meyer, T, Ludolph, AC, Goris, A, van Damme, P, Robberecht, W, Shatunov, A, Fogh, I, Andersen, PM, D'Alfonso, S, Hardiman, O, Cronin, S, Rujescu, D, Al-Chalabi, A, Landers, JE, Silani, V, van den Berg, LH & Veldink, JH 2014, 'Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: A multicenter survival study', Neurobiology of Aging, vol. 35, no. 10. https://doi.org/10.1016/j.neurobiolaging.2014.04.014

van Doormaal, Perry T C ; Ticozzi, Nicola ; Gellera, Cinzia ; Ratti, Antonia ; Taroni, Franco ; Chiò, Adriano ; Calvo, Andrea ; Mora, Gabriele ; Restagno, Gabriella ; Traynor, Bryan J. ; Birve, Anna ; Lemmens, Robin ; van Es, Michael A. ; Saris, Christiaan G J ; Blauw, Hylke M. ; van Vught, Paul W J ; Groen, Ewout J N ; Corrado, Lucia ; Mazzini, Letizia ; Del Bo, Roberto ; Corti, Stefania ; Waibel, Stefan ; Meyer, Thomas ; Ludolph, Albert C. ; Goris, An ; van Damme, Philip ; Robberecht, Wim ; Shatunov, Aleksey ; Fogh, Isabella ; Andersen, Peter M. ; D'Alfonso, Sandra ; Hardiman, Orla ; Cronin, Simon ; Rujescu, Dan ; Al-Chalabi, Ammar ; Landers, John E. ; Silani, Vincenzo ; van den Berg, Leonard H. ; Veldink, Jan H. / Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis : A multicenter survival study. In: Neurobiology of Aging. 2014 ; Vol. 35, No. 10.

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abstract = "Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n= 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group.",

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AU - Ratti, Antonia

AU - Taroni, Franco

AU - Chiò, Adriano

AU - Calvo, Andrea

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AU - van Es, Michael A.

AU - Saris, Christiaan G J

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AU - Mazzini, Letizia

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AU - Waibel, Stefan

AU - Meyer, Thomas

AU - Ludolph, Albert C.

AU - Goris, An

AU - van Damme, Philip

AU - Robberecht, Wim

AU - Shatunov, Aleksey

AU - Fogh, Isabella

AU - Andersen, Peter M.

AU - D'Alfonso, Sandra

AU - Hardiman, Orla

AU - Cronin, Simon

AU - Rujescu, Dan

AU - Al-Chalabi, Ammar

AU - Landers, John E.

AU - Silani, Vincenzo

AU - van den Berg, Leonard H.

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