Abstract
Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n= 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group.
Original language | English |
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Journal | Neurobiology of Aging |
Volume | 35 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- Amyotrophic lateral sclerosis
- Genome-wide association study
- KIFAP3
- Kinesin-associated protein 3 gene
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
- Ageing
- Developmental Biology
- Geriatrics and Gerontology