Analysis of the retinoic acid receptor α gene as a candidate for the pulmonary adenoma resistance 1 gene

Manuela Gariboldi, Valerie Vivat, Laura De Gregorio, Giacomo Manenti, Elena Chiariello, F. Stefania Falvella, Marco A. Pierotti, Tommaso A. Dragani

Research output: Contribution to journalArticlepeer-review

Abstract

The retinoic acid receptor α (Rara) gene, which maps in the same region as the pulmonary adenoma resistance (Par 1) locus on mouse chromosome 11 (Manenti G et al., Nature Genet 12:455-457, 1996), was tested as a candidate gene for Par 1. We report here the analysis of loss of heterozygosity, nucleotide sequence comparison, gene expression, and biochemical activity of the Rara gene from the Mus spretus (Par1/+) and A/J (Par1/-) mouse strains. The two Rara alleles were distinguished by two amino-acid variations but had similar biochemical activity and expression levels, leading to the exclusion of Rara as a candidate Par 1 gene.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalMolecular Carcinogenesis
Volume21
Issue number1
DOIs
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology

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