The retinoic acid receptor α (Rara) gene, which maps in the same region as the pulmonary adenoma resistance (Par 1) locus on mouse chromosome 11 (Manenti G et al., Nature Genet 12:455-457, 1996), was tested as a candidate gene for Par 1. We report here the analysis of loss of heterozygosity, nucleotide sequence comparison, gene expression, and biochemical activity of the Rara gene from the Mus spretus (Par1/+) and A/J (Par1/-) mouse strains. The two Rara alleles were distinguished by two amino-acid variations but had similar biochemical activity and expression levels, leading to the exclusion of Rara as a candidate Par 1 gene.
|Number of pages||4|
|Publication status||Published - 1998|
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology