Abstract
The fimA gene coding for the major component (fimbrin) of type 1 fimbriae was mapped within the Salmonella typhi fim gene cluster, and its nucleotide sequence determined. The deduced amino acid sequence of S. typhi fimbrin is highly homologous to that of S. typhimurium type 1 fimbrin and showed similarity to that of other enterobacterial type 1 fimbrins. Downstream of fimA, an open reading frame was found, named fimI, able to encode a fimbrin-like protein. The fimI product could represent the counterpart, in type 1 fimbriae, of the PapH protein involved in cell anchoring and length modulation of Escherichia coli Pap pili. This genetic organization was found to be common to other Salmonella serovars, including S. typhimurium and S. choleraesuis.
Original language | English |
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Pages (from-to) | 259-265 |
Number of pages | 7 |
Journal | FEMS Microbiology Letters |
Volume | 114 |
Issue number | 3 |
Publication status | Published - Dec 15 1993 |
Keywords
- fim genes
- fimA gene
- fimI gene
- Salmonella typhi
- Type 1 fimbriae
ASJC Scopus subject areas
- Genetics
- Molecular Biology
- Applied Microbiology and Biotechnology
- Microbiology