Analysis of the Salmonella fim gene cluster: Identification of a new gene (fimI) encoding a fimbrin-like protein and located downstream from the fimA gene

Gian Maria Rossolini, Patrizia Muscas, Alessandra Chiesurin, Giuseppe Satta

Research output: Contribution to journalArticle

Abstract

The fimA gene coding for the major component (fimbrin) of type 1 fimbriae was mapped within the Salmonella typhi fim gene cluster, and its nucleotide sequence determined. The deduced amino acid sequence of S. typhi fimbrin is highly homologous to that of S. typhimurium type 1 fimbrin and showed similarity to that of other enterobacterial type 1 fimbrins. Downstream of fimA, an open reading frame was found, named fimI, able to encode a fimbrin-like protein. The fimI product could represent the counterpart, in type 1 fimbriae, of the PapH protein involved in cell anchoring and length modulation of Escherichia coli Pap pili. This genetic organization was found to be common to other Salmonella serovars, including S. typhimurium and S. choleraesuis.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalFEMS Microbiology Letters
Volume114
Issue number3
Publication statusPublished - Dec 15 1993

Fingerprint

Multigene Family
Salmonella
Salmonella typhi
Genes
Proteins
Fimbriae Proteins
Open Reading Frames
Amino Acid Sequence
plastin
Escherichia coli

Keywords

  • fim genes
  • fimA gene
  • fimI gene
  • Salmonella typhi
  • Type 1 fimbriae

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Analysis of the Salmonella fim gene cluster : Identification of a new gene (fimI) encoding a fimbrin-like protein and located downstream from the fimA gene. / Rossolini, Gian Maria; Muscas, Patrizia; Chiesurin, Alessandra; Satta, Giuseppe.

In: FEMS Microbiology Letters, Vol. 114, No. 3, 15.12.1993, p. 259-265.

Research output: Contribution to journalArticle

Rossolini, Gian Maria ; Muscas, Patrizia ; Chiesurin, Alessandra ; Satta, Giuseppe. / Analysis of the Salmonella fim gene cluster : Identification of a new gene (fimI) encoding a fimbrin-like protein and located downstream from the fimA gene. In: FEMS Microbiology Letters. 1993 ; Vol. 114, No. 3. pp. 259-265.
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