Analysis of the secondary endodontic lesions focusing on the extraradicular microorganisms: an overview

Massimo Del Fabbro, Lakshman P. Samaranayake, Alessandra Lolato, Tommaso Weinstein, Silvio Taschieri

Research output: Contribution to journalArticlepeer-review


The present study aimed at reviewing the literature on extraradicular infections of endodontically treated teeth, summarizing the main hypotheses on etiopathogenesis and describing the most suitable techniques to identify the composition of pathogenic extraradicular microorganisms. Medline database was searched using the keywords "Apical biofilm," "extraradicular infection," "secondary endodontic lesion," "endodontic retreatment," "biofilm" either alone or combined with AND. A further hand search was performed on the main endodontic journals. The most frequent bacterial species identified in different studies and with different techniques may vary considerably. Although the presence of some species of microorganisms seems to be determinant, the true origin of extraradicular infection is still undetermined. The literature analysis showed marked differences in methodology, materials, aims, and techniques adopted, which led to highly heterogeneous outcomes. The picture emerging from this review is that extraradicular infection is likely a multifactorial disease that requires further systematic investigation using standardized techniques.

Original languageEnglish
Pages (from-to)245-254
Number of pages10
JournalJournal of investigative and clinical dentistry
Issue number4
Publication statusPublished - Nov 1 2014


  • extraradicular lesion
  • extraradicular microorganisms
  • molecular diagnostic techniques
  • scanning electron microscopy
  • secondary endodontic lesion

ASJC Scopus subject areas

  • Medicine(all)


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