Analysis of TP53 codon 72 polymorphism in HPV-positive and HPV-negative penile carcinoma

Maria Lina Tornesello, Maria Luisa Duraturo, Valentina Guida, Simona Losito, Gerardo Botti, Silvana Pilotti, Bernardina Stefanon, Giuseppe De Palo, Luigi Buonaguro, Franco M. Buonaguro

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Abstract

The association of the p53 polymorphism at codon 72 and susceptibility to develop human papillomavirus (HPV)-related cancer has been investigated in several studies with controversial results. In this study, 78 penile squamous cell carcinoma biopsies (n = 17 from Uganda, n = 61 from Italy) and blood samples from 150 healthy controls (n = 57 from Uganda, n = 93 from Italy) have been analyzed for the arginine and proline allele distribution. Among Ugandan cases the heterozygous, proline homozygous and arginine homozygous genotype frequency was 41.2%, 52.9% and 5.9%, respectively, and among controls was 40.3%, 54.4%, and 5.3%, respectively (P = 0.9917). Conversely, among Italian cases genotype distribution was 42.6%, 4.9%, and 52.5%, and among controls was 34.4%, 7.5%, and 58.1%, respectively (P = 0.5343). No significant differences in arginine and proline allele distribution were observed when the cases were stratified by HPV status. Therefore, no evidence of association between homozygosity for p53 arginine and HPV-related or HPV-unrelated penile squamous cell carcinoma was observed neither among Ugandan nor among Italian populations.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalCancer Letters
Volume269
Issue number1
DOIs
Publication statusPublished - Sep 28 2008

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Keywords

  • Cancer risk
  • Genetic susceptibility
  • Human papillomavirus
  • Penile squamous cell carcinoma
  • TP53 polymorphism

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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