Analysis of treatment failures and survival of patients with uterine papillary serous carcinoma: A cooperation task force (CTF) study

Angiolo Gadducci, Stefania Cosio, Fabio Landoni, Tiziano Maggino, Paolo Zola, Luca Fuso, Enrico Sartori

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Abstract

Objective: To assess the pattern of failures and the survival of patients with uterine papillary serous carcinoma (UPSC). Methods: The hospital records of 119 women with UPSC were reviewed. Surgery was the initial therapy for all the cases. The median follow-up of survivors was 133 months (range, 3Y216 months). Results: Postoperative treatment was used in 98 patients (82.4%). Adjuvant treatment was radiotherapy in 25 women, chemotherapy in 61 women, and chemotherapy plus radiotherapy in 12 women. Tumor recurred in 44 (37.0%) of the 119 patients, after a median time of 15.1 months. Relapse was symptomatic in 15 patients (34.1%), and recurrent disease involved peritoneum or distant sites in 26 (66.7%) of the 39 patients for whom the site of failure was known. Five- and 10-year survival rates were 61.8% and 54.6%, respectively. Survival was related to disease stage (P G 0.0001). Among patients with advanced tumor, 5-year survival was lower in women who had macroscopic residual disease after surgery than in those who had not (15.4% vs 37.5%; P = 0.08). Distant failures were higher in women with histologically proven positive nodes than in those with negative nodes (28.6% vs 9.1%; P = 0.048). There was a trend to better survival for patients with stage I to stage II disease who underwent chemotherapy when compared with those who did not. Conclusions: Uterine papillary serous carcinoma has an aggressive clinical behavior with a great tendency to recur especially in peritoneal and distant sites. Tumor stage is a strong prognostic factor, whereas the role of adjuvant treatment is still uncertain.

Original languageEnglish
Pages (from-to)1355-1360
Number of pages6
JournalInternational Journal of Gynecological Cancer
Volume22
Issue number8
DOIs
Publication statusPublished - 2012

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Keywords

  • Chemotherapy
  • Pattern of failure
  • Radiotherapy
  • Surgical staging
  • Uterine papillary serous carcinoma

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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