Analytical and pharmacokinetic studies on butyrophenones

F. Marcucci, E. Mussini, L. Airoldi, R. Fanelli, A. Frigerio, F. De Nadai, A. Bizzi, M. Rizzo, P. L. Morselli, S. Garattini

Research output: Contribution to journalArticle

Abstract

A method to measure butyrophenones as such in GLC was developed and applied for the determination of these drugs in biological materials. Haloperidol and trifluperidol show many properties in common when they are injected. They penetrate very rapidly into brain where they reach levels several times higher than in plasma. The brain concentration able to inhibit completely the effects of amphetamine is for both drugs between 30 and 40 ng/g. Haloperidol and trifluperidol are different in their capacity to accumulate in the adipose tissue in vivo and in vitro. The GLC method to measure butyrophenones has been employed for determining haloperidol in the plasma of psychiatric patients treated with this drug for therapeutical reasons.

Original languageEnglish
Pages (from-to)321-332
Number of pages12
JournalClinica Chimica Acta
Volume34
Issue number2
DOIs
Publication statusPublished - 1971

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

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    Marcucci, F., Mussini, E., Airoldi, L., Fanelli, R., Frigerio, A., De Nadai, F., Bizzi, A., Rizzo, M., Morselli, P. L., & Garattini, S. (1971). Analytical and pharmacokinetic studies on butyrophenones. Clinica Chimica Acta, 34(2), 321-332. https://doi.org/10.1016/0009-8981(71)90186-0