Abstract
Over the last two decades, the role played by phytocannabinoids and endocannabinoids in medicine has gained increasing interest in the scientific community. Upon identification of the plant compound Δ9-tetrahydrocannabinol (THC) and of the endogenous substance anandamide (AEA), different methodological approaches and innovative techniques have been developed, in order to evaluate the content of these molecules in various human matrices. In this review, we discuss the analytical methods that are currently used for the identification of phytocannabinoids and endocannabinoids, and we summarize the benefits and limitations of these procedures. Moreover, we provide an overview of the main biological matrices that have been analyzed to date for qualitative detection and quantitative determination of these compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 7-16 |
| Number of pages | 10 |
| Journal | Drug Testing and Analysis |
| Volume | 6 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Jan 2014 |
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Keywords
- Δ-tetrahydrocannabinol
- Anandamide
- Liquid chromatography
- Mass spectrometry
ASJC Scopus subject areas
- Analytical Chemistry
- Environmental Chemistry
- Pharmaceutical Science
- Spectroscopy
Cite this
Analytical approaches for the determination of phytocannabinoids and endocannabinoids in human matrices. / Battista, Natalia; Sergi, Manuel; Montesano, Camilla; Napoletano, Sabino; Compagnone, Dario; Maccarrone, Mauro.
In: Drug Testing and Analysis, Vol. 6, No. 1-2, 01.2014, p. 7-16.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analytical approaches for the determination of phytocannabinoids and endocannabinoids in human matrices
AU - Battista, Natalia
AU - Sergi, Manuel
AU - Montesano, Camilla
AU - Napoletano, Sabino
AU - Compagnone, Dario
AU - Maccarrone, Mauro
PY - 2014/1
Y1 - 2014/1
N2 - Over the last two decades, the role played by phytocannabinoids and endocannabinoids in medicine has gained increasing interest in the scientific community. Upon identification of the plant compound Δ9-tetrahydrocannabinol (THC) and of the endogenous substance anandamide (AEA), different methodological approaches and innovative techniques have been developed, in order to evaluate the content of these molecules in various human matrices. In this review, we discuss the analytical methods that are currently used for the identification of phytocannabinoids and endocannabinoids, and we summarize the benefits and limitations of these procedures. Moreover, we provide an overview of the main biological matrices that have been analyzed to date for qualitative detection and quantitative determination of these compounds.
AB - Over the last two decades, the role played by phytocannabinoids and endocannabinoids in medicine has gained increasing interest in the scientific community. Upon identification of the plant compound Δ9-tetrahydrocannabinol (THC) and of the endogenous substance anandamide (AEA), different methodological approaches and innovative techniques have been developed, in order to evaluate the content of these molecules in various human matrices. In this review, we discuss the analytical methods that are currently used for the identification of phytocannabinoids and endocannabinoids, and we summarize the benefits and limitations of these procedures. Moreover, we provide an overview of the main biological matrices that have been analyzed to date for qualitative detection and quantitative determination of these compounds.
KW - Δ-tetrahydrocannabinol
KW - Anandamide
KW - Liquid chromatography
KW - Mass spectrometry
UR - http://www.scopus.com/inward/record.url?scp=84892453118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892453118&partnerID=8YFLogxK
U2 - 10.1002/dta.1574
DO - 10.1002/dta.1574
M3 - Article
C2 - 24218186
AN - SCOPUS:84892453118
VL - 6
SP - 7
EP - 16
JO - Drug Testing and Analysis
JF - Drug Testing and Analysis
SN - 1942-7603
IS - 1-2
ER -