Analytical approaches for the determination of phytocannabinoids and endocannabinoids in human matrices

Natalia Battista; Manuel Sergi; Camilla Montesano; Sabino Napoletano; Dario Compagnone; Mauro Maccarrone

doi:10.1002/dta.1574

Analytical approaches for the determination of phytocannabinoids and endocannabinoids in human matrices

Natalia Battista, Manuel Sergi, Camilla Montesano, Sabino Napoletano, Dario Compagnone, Mauro Maccarrone

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Over the last two decades, the role played by phytocannabinoids and endocannabinoids in medicine has gained increasing interest in the scientific community. Upon identification of the plant compound Δ⁹-tetrahydrocannabinol (THC) and of the endogenous substance anandamide (AEA), different methodological approaches and innovative techniques have been developed, in order to evaluate the content of these molecules in various human matrices. In this review, we discuss the analytical methods that are currently used for the identification of phytocannabinoids and endocannabinoids, and we summarize the benefits and limitations of these procedures. Moreover, we provide an overview of the main biological matrices that have been analyzed to date for qualitative detection and quantitative determination of these compounds.

Original language	English
Pages (from-to)	7-16
Number of pages	10
Journal	Drug Testing and Analysis
Volume	6
Issue number	1-2
DOIs	https://doi.org/10.1002/dta.1574
Publication status	Published - Jan 2014

Keywords

Δ-tetrahydrocannabinol
Anandamide
Liquid chromatography
Mass spectrometry

ASJC Scopus subject areas

Analytical Chemistry
Environmental Chemistry
Pharmaceutical Science
Spectroscopy

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abstract = "Over the last two decades, the role played by phytocannabinoids and endocannabinoids in medicine has gained increasing interest in the scientific community. Upon identification of the plant compound Δ9-tetrahydrocannabinol (THC) and of the endogenous substance anandamide (AEA), different methodological approaches and innovative techniques have been developed, in order to evaluate the content of these molecules in various human matrices. In this review, we discuss the analytical methods that are currently used for the identification of phytocannabinoids and endocannabinoids, and we summarize the benefits and limitations of these procedures. Moreover, we provide an overview of the main biological matrices that have been analyzed to date for qualitative detection and quantitative determination of these compounds.",

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AU - Compagnone, Dario

AU - Maccarrone, Mauro

PY - 2014/1

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Analytical approaches for the determination of phytocannabinoids and endocannabinoids in human matrices

Abstract

Keywords

ASJC Scopus subject areas

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