Analytical Performance of 10 High-Volume Clinical Chemistry Assays on the Alinity c System

Magdalena Krintus, Jon Ardanza Fernandez, Christine Chesters, Rossana Colla, Clare Ford, Daniele Frattolillo, Ursula Köller, Jacques Mairesse, Daniel Martinez Jimenez, Jérôme Motol, Kevin Padmore, Hayley Sharrod-Cole, Grazyna Sypniewska

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Early access for routine testing with the Alinity c clinical chemistry system (Abbot Laboratories) presented the opportunity to characterize the analytical performance of multiple analytes across clinical laboratories in Europe. Methods: A total of 8 laboratories from 7 European countries evaluated 10 high-volume chemistry assays on the Alinity c system for imprecision, linearity, and accuracy by method comparison to the routine ARCHITECT (Abbott Laboratories) method. Results: Within-run precision was less than 4% coefficient of variation (CV), with total imprecision less than 5.6% CV for 5- and 20-day evaluations. Linearity met expectations, and method comparison showed strong correlation between the Alinity and ARCHITECT methods, with overall linear correlation coefficient between 0.980 to 1.000 and slopes of the regression line between 0.963 and 1.034. Mean percentage difference between the results of assays run on the ARCHITECT and the Alinity ranged between -1.7% and 2.15%. Conclusions: Our results demonstrated acceptable key analytical performance across all assays tested at each participating laboratory.

Original languageEnglish
JournalLaboratory Medicine
Volume50
Issue number1
DOIs
Publication statusPublished - Jan 1 2019
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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