Abstract
Some adverse reactions to iodinated contrast material (ICM) are considered allergy-like, with cutaneous, cardiovascular, respiratory, and digestive symptoms. Allergy-like reactions are usually unpredictable. Reactions are more frequent with ionic than with nonionic material, but the frequency of deaths is almost identical. In a recent study, 20 severe unexpected reactions to ICM, including 10 life-threatening reactions and one death, were investigated by measuring mediators in blood, within the first minutes or hours of reaction. The responsible ICMs were mostly ionic materials. Histamine and tryptase release correlated with the severity of the reaction. Specific IgE against the responsible ICM was significantly higher in reactors than in controls. A few patients had positive skin tests to the administered ICM, suggesting type-1 allergic reaction. Only 2.4% and 3.1% of the cases yielded a positive IgE-RIA, in a second retrospective study which included 165 patients recruited during a 4-year period. In conclusion, IgE- mediated anaphylaxis is rare, but it may be one of the possible mechanisms of severe adverse reactions to ICM.
| Original language | English |
|---|---|
| Pages (from-to) | 13-16 |
| Number of pages | 4 |
| Journal | Allergy: European Journal of Allergy and Clinical Immunology, Supplement |
| Volume | 54 |
| Issue number | 58 |
| Publication status | Published - 1999 |
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Keywords
- Contrast media/adverse effects
- Immediate hypersensitivity
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Anaphylactoid and anaphylactic reactions to iodinated contrast material. / Laroche, Dominique; Namour, F.; Lefrançois, C.; Aimone-Gastin, I.; Romano, A.; Sainte-Laudy, J.; Laxenaire, M. C.; Guéant, J. L.
In: Allergy: European Journal of Allergy and Clinical Immunology, Supplement, Vol. 54, No. 58, 1999, p. 13-16.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anaphylactoid and anaphylactic reactions to iodinated contrast material
AU - Laroche, Dominique
AU - Namour, F.
AU - Lefrançois, C.
AU - Aimone-Gastin, I.
AU - Romano, A.
AU - Sainte-Laudy, J.
AU - Laxenaire, M. C.
AU - Guéant, J. L.
PY - 1999
Y1 - 1999
N2 - Some adverse reactions to iodinated contrast material (ICM) are considered allergy-like, with cutaneous, cardiovascular, respiratory, and digestive symptoms. Allergy-like reactions are usually unpredictable. Reactions are more frequent with ionic than with nonionic material, but the frequency of deaths is almost identical. In a recent study, 20 severe unexpected reactions to ICM, including 10 life-threatening reactions and one death, were investigated by measuring mediators in blood, within the first minutes or hours of reaction. The responsible ICMs were mostly ionic materials. Histamine and tryptase release correlated with the severity of the reaction. Specific IgE against the responsible ICM was significantly higher in reactors than in controls. A few patients had positive skin tests to the administered ICM, suggesting type-1 allergic reaction. Only 2.4% and 3.1% of the cases yielded a positive IgE-RIA, in a second retrospective study which included 165 patients recruited during a 4-year period. In conclusion, IgE- mediated anaphylaxis is rare, but it may be one of the possible mechanisms of severe adverse reactions to ICM.
AB - Some adverse reactions to iodinated contrast material (ICM) are considered allergy-like, with cutaneous, cardiovascular, respiratory, and digestive symptoms. Allergy-like reactions are usually unpredictable. Reactions are more frequent with ionic than with nonionic material, but the frequency of deaths is almost identical. In a recent study, 20 severe unexpected reactions to ICM, including 10 life-threatening reactions and one death, were investigated by measuring mediators in blood, within the first minutes or hours of reaction. The responsible ICMs were mostly ionic materials. Histamine and tryptase release correlated with the severity of the reaction. Specific IgE against the responsible ICM was significantly higher in reactors than in controls. A few patients had positive skin tests to the administered ICM, suggesting type-1 allergic reaction. Only 2.4% and 3.1% of the cases yielded a positive IgE-RIA, in a second retrospective study which included 165 patients recruited during a 4-year period. In conclusion, IgE- mediated anaphylaxis is rare, but it may be one of the possible mechanisms of severe adverse reactions to ICM.
KW - Contrast media/adverse effects
KW - Immediate hypersensitivity
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UR - http://www.scopus.com/inward/citedby.url?scp=0033491829&partnerID=8YFLogxK
M3 - Article
C2 - 10735643
AN - SCOPUS:0033491829
VL - 54
SP - 13
EP - 16
JO - Allergy: European Journal of Allergy and Clinical Immunology, Supplement
JF - Allergy: European Journal of Allergy and Clinical Immunology, Supplement
SN - 0108-1675
IS - 58
ER -