Anaphylaxis to plant-foods and pollen allergens in patients with lipid transfer protein syndrome

Riccardo Asero, Valerio Pravettoni

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Nonspecific lipid transfer protein (LTP) is the main cause of primary food allergy in adults living in the Mediterranean area. The way allergic patients get sensitized to this protein is all but established, and the clinical expression of sensitization is extremely variable, ranging from long-lasting symptomless sensitization to severe anaphylaxis. Such variability is seemingly due to the presence/absence of a number of cofactors. RECENT FINDINGS: The possibility that LTP sensitization occurs via the inhalation of LTP-containing pollen particles seems unlikely; in contrast, peach particles containing the protein seem able to sensitize both via the airways and the skin. Cosensitization to pollen allergens as well as to labile plant food allergens makes LTP allergy syndrome less severe. In some LTP sensitized subjects clinical food allergy occurs only in the presence of cofactors such as exercise, NSAIDs, or chronic urticaria. SUMMARY: Lipid transfer protein allergy syndrome shows some peculiarities that are unique in the primary food allergy panorama: geographical distribution, frequent asymptomatic sensitization, frequent need for cofactors, and reduced severity when pollen allergy is present. Future studies will have to address these points as the results may have favorable effects on other, more severe, types of food allergy.

Original languageEnglish
Pages (from-to)379-385
Number of pages7
JournalCurrent Opinion in Allergy and Clinical Immunology
Volume13
Issue number4
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Edible Plants
Anaphylaxis
Pollen
Allergens
Food Hypersensitivity
Hypersensitivity
Seasonal Allergic Rhinitis
Urticaria
Non-Steroidal Anti-Inflammatory Agents
Inhalation
Proteins
lipid transfer protein
Exercise
Skin

Keywords

  • Cofactors
  • Food allergy
  • Lipid transfer protein
  • Pollen allergy
  • Sensitization

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Anaphylaxis to plant-foods and pollen allergens in patients with lipid transfer protein syndrome. / Asero, Riccardo; Pravettoni, Valerio.

In: Current Opinion in Allergy and Clinical Immunology, Vol. 13, No. 4, 08.2013, p. 379-385.

Research output: Contribution to journalArticle

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