Anaplastic large cell lymphoma treated with a leukemia-like therapy: Report of the Italian Association of Pediatric Hematology and Oncology (AIEOP) LNH-92 protocol

Angelo Rosolen, Maria Pillon, Alberto Garaventa, Roberta Burnelli, Emanuele S. D'Amore, Maria Giuliano, Margherita Comis, Simone Cesaro, Katia Tettoni, Maria Luisa Moleti, Paolo Tamaro, Gianluca Visintin, Luigi Zanesco

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND. Childhood anaplastic large cell lymphoma (ALCL) is a well defined entity with a rather poor prognosis. Different approaches have been adopted in the treatment of ALCL in various cooperative trials, including short high-dose intensive therapy and leukemia-like protocols. In the early 1990s, the Italian Association of Pediatric Hematology and Oncology (AIEOP) initiated a multicenter trial for the treatment of ALCL based on a modified LSA2-L2 protocol. METHODS. Thirty-four consecutive eligible children with newly diagnosed ALCL were enrolled in the AIEOP LNH-92 protocol. Treatment was comprised of an induction of remission phase, followed by consolidation and maintenance for a total duration of 24 months, independently of disease stage. RESULTS. Thirty of 34 patients (88%) achieved complete disease remission and 8 patients experienced disease recurrence. With a median follow-up of 8.4 years, the probabilities of survival and event-free survival were 85% (range, 79-91%) and 65% (range, 57-73%), respectively. Therapy was well tolerated and hematologic toxicity was the most frequent toxicity. CONCLUSIONS. The leukemia-like protocol AIEOP LNH-92 was found to be an effective treatment for childhood ALCL. Its long duration may be beneficial to specific patient subgroups, but optimal treatment duration in ALCL remains to be elucidated.

Original languageEnglish
Pages (from-to)2133-2140
Number of pages8
JournalCancer
Volume104
Issue number10
DOIs
Publication statusPublished - Nov 15 2005

Keywords

  • Anaplastic large cell lymphoma
  • Child
  • LSA2-L2
  • Outcome
  • Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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