Anaplastic large-cell lymphomas of B-cell phenotype are anaplastic lymphoma kinase (ALK) negative and belong to the spectrum of diffuse large B- cell lymphomas

Eugenia Haralambieva, Karen A F Pulford, Laurence Lamant, Stefano Pileri, Giovanna Roncador, Kevin C. Gatter, Georges Delsol, David Y. Mason

Research output: Contribution to journalArticle

Abstract

There is controversy in the literature as to whether anaplastic large- cell lymphoma of B-cell phenotype is related to the t(2;5)-positive T- or 'null' cell lymphoma of the same morphology. We report a study of 24 lymphomas with morphological features of anaplastic large-cell lymphoma which expressed one or more B-cell markers and lacked T-lineage markers. Clinical features were more in keeping with large B-cell lymphoma than with classical t(2;5)-positive anaplastic large-cell lymphoma, and immunostaining for anaplastic lymphoma kinase (ALK) protein provided no evidence for the (2;5) translocation (or one of its variants). The staining patterns for CD20 and CD79 were typical of diffuse large B-cell lymphoma, CD30 expression was variable, and most cases (15/22) lacked epithelial membrane antigen (EMA). These findings support the view that 'B-cell anaplastic large-cell lymphoma' is unrelated to t(2:5)-positive (ALK-positive) lymphoma, and that it represents a morphological pattern occasionally encountered among diffuse large B-cell lymphomas. By the same reasoning, most tumours diagnosed as 'ALK-negative anaplastic large-cell lymphoma of T-cell or null phenotype' probably belong to the spectrum of peripheral T-cell lymphomas.

Original languageEnglish
Pages (from-to)584-591
Number of pages8
JournalBritish Journal of Haematology
Volume109
Issue number3
DOIs
Publication statusPublished - 2000

Keywords

  • (2;5) translocation
  • ALK protein
  • Anaplastic large-cell lymphoma
  • B-cell markers
  • Diffuse large B-cell lymphoma

ASJC Scopus subject areas

  • Hematology

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