Anaplastic large-cell periprosthetic lymphoma of the breast: Could fibrin be an early radiological indicator of the presence of disease?

Daniele La Forgia, Marco Moschetta, Alfonso Fausto, Daniela Cutrignelli, Rosalba Dentamaro, Liliana Losurdo, Arianna Maiorella, Cosmo Maurizio Ressa, Anna Scattone, Michele Telegrafo, Aurelio Portincasa

Research output: Contribution to journalArticle

Abstract

Purpose: The onset characteristics of the anaplastic large cell lymphoma (BI-ALCL) are non-specific and the diagnosis is often difficult and based on clinical suspicion and cytological sampling. The presence of non-pathognomonic radiological signs may delay the diagnosis of BI-ALCL, influencing patient prognosis. This could have an important social impact, considering that the incidence of BI-ALCL correlates with the number of prosthetic implants, which is in constant increase worldwide. The aim of this study was to verify if fibrin can represent a potentially early radiological sign of the disease. Methods: In this study, we present two cases of our series and review the previous studies already described in the literature, searching for any early radiological sign of the disease and reporting a diagnostic work-up process for an early diagnosis. Results: Signs clearly recognizable only of magnetic resonance imaging (MRI) were the following: thickening and hy-peremia of the fibrous capsule with seroma and amorphous material (fibrin) present in 8 out of 10 cases (80%), detected on MRI (certain or doubtful). Conclusion: The presence of fibrin in the periprosthetic effusion, well detectable by MRI, could represent an early pathognomonic sign of the disease.

Original languageEnglish
Pages (from-to)1889-1897
Number of pages9
JournalJournal of B.U.ON.
Volume24
Issue number5
Publication statusPublished - Jan 1 2019

Keywords

  • Anaplastic large-cell lymphoma
  • Breast implant
  • Breast magnetic resonance imaging
  • Periprosthetic anaplastic lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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  • Cite this

    La Forgia, D., Moschetta, M., Fausto, A., Cutrignelli, D., Dentamaro, R., Losurdo, L., Maiorella, A., Ressa, C. M., Scattone, A., Telegrafo, M., & Portincasa, A. (2019). Anaplastic large-cell periprosthetic lymphoma of the breast: Could fibrin be an early radiological indicator of the presence of disease? Journal of B.U.ON., 24(5), 1889-1897.