Anaplastic lymphoma kinase expression as a marker of malignancy. Application to a case of anaplastic large cell lymphoma with huge granulomatous reaction

P. P. Piccaluga, S. Ascani, G. F. Orcioni, M. Piccioli, Jr Pileri A., B. Falini, S. A. Pileri

Research output: Contribution to journalArticle

Abstract

Anaplastic lymphoma kinase expression as a marker of malignanancy. A Anaplastic large cell lymphoma (ALCL) shows a wide morphologic spectrum, including the occurrence of reactive components obscuring the neoplastic population. This makes its distinction from hyperimmune reaction difficult. The authors describe an ALCL in a girl who had a tick bite 20 days prior to clinical presentation. She developed a huge epitholioid reaction (an unprecedented finding for this tumor). The diagnostic controversies were solved by applying the ALKc antibody against anaplastic large cell lymphoma kinase (ALK), in conjunction with reagents anti-nucleophosmin (NPM), which showed the typical staining pattern observed in ALCL carrying t(2;5). Comprised within the epithelloid component there were large anaplastic cells and small-medium sized atypical elements displaying strong nuclear and cytoplasmic positivity for ALK and NPM (N-terminal region). This pattern, never observed in normal lymphocytes, corresponds to the presence of the product of the hybrid gene NPM/ALK produced by t(2;5). Following the diagnosis, the patient - whose general conditions were critical - underwent aggressive chemotherapy, achieving complete remission. (C) 2000, Ferrata Storti Foundation.

Original languageEnglish
Pages (from-to)978-981
Number of pages4
JournalHaematologica
Volume85
Issue number9
Publication statusPublished - 2000

Keywords

  • Anaplastic large cell lymphoma
  • Chemotherapy
  • Chromosomal aberration
  • Immunophenotype

ASJC Scopus subject areas

  • Hematology

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